Advance in new oral drugs for multiple sclerosis
Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system and represents one of the most common causes of chronic neurologic disability. Until recently, major treatments have relied on agents by injection which can induce injection ⁃related adverse events....
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Tianjin Huanhu Hospital
2012-04-01
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doaj-92f9be30263a4978a64e411b2fd51ab32020-11-24T23:01:49ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312012-04-01122147151139Advance in new oral drugs for multiple sclerosisGuan⁃en ZHOUZhong⁃ping ANMultiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system and represents one of the most common causes of chronic neurologic disability. Until recently, major treatments have relied on agents by injection which can induce injection ⁃related adverse events. The parenteral route of administration may affect the compliance with therapy in multiple sclerosis. Therefore, there is a need for the development of oral agents. The research of five oral drugs (cladribine, fingolimod, teriflunomide, laquinimod and dimethyl fumarate), is carrying out in Phase Ⅲ study. In this article, we review the undergoing clinical trials of these five oral agents. DOI:10.3969/j.issn.1672⁃6731.2012.02.011http://www.cjcnn.org/index.php/cjcnn/article/view/140Multiple sclerosisDrug therapyClinical trialsReview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guan⁃en ZHOU Zhong⁃ping AN |
spellingShingle |
Guan⁃en ZHOU Zhong⁃ping AN Advance in new oral drugs for multiple sclerosis Chinese Journal of Contemporary Neurology and Neurosurgery Multiple sclerosis Drug therapy Clinical trials Review |
author_facet |
Guan⁃en ZHOU Zhong⁃ping AN |
author_sort |
Guan⁃en ZHOU |
title |
Advance in new oral drugs for multiple sclerosis |
title_short |
Advance in new oral drugs for multiple sclerosis |
title_full |
Advance in new oral drugs for multiple sclerosis |
title_fullStr |
Advance in new oral drugs for multiple sclerosis |
title_full_unstemmed |
Advance in new oral drugs for multiple sclerosis |
title_sort |
advance in new oral drugs for multiple sclerosis |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2012-04-01 |
description |
Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system and represents one of the most common causes of chronic neurologic disability. Until recently, major treatments have relied on agents by injection which can induce injection ⁃related adverse events. The parenteral route of administration may affect the compliance with therapy in multiple sclerosis. Therefore, there is a need for the development of oral agents. The research of five oral drugs (cladribine, fingolimod, teriflunomide, laquinimod and dimethyl fumarate), is carrying out in Phase Ⅲ study. In this article, we review the undergoing clinical trials of these five oral agents.
DOI:10.3969/j.issn.1672⁃6731.2012.02.011 |
topic |
Multiple sclerosis Drug therapy Clinical trials Review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/140 |
work_keys_str_mv |
AT guanenzhou advanceinneworaldrugsformultiplesclerosis AT zhongpingan advanceinneworaldrugsformultiplesclerosis |
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1725638634630021120 |