Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.

Bibliographic Details
Main Authors: Oscar Ortega-Recalde, Robert C. Day, Neil J. Gemmell, Timothy A. Hore
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10894-7
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spelling doaj-930144fede1144be9a981b3a57912b2a2021-05-11T11:54:52ZengNature Publishing GroupNature Communications2041-17232019-07-0110111010.1038/s41467-019-10894-7Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisationOscar Ortega-Recalde0Robert C. Day1Neil J. Gemmell2Timothy A. Hore3Department of Anatomy, University of OtagoDepartment of Biochemistry, University of OtagoDepartment of Anatomy, University of OtagoDepartment of Anatomy, University of OtagoGermline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.https://doi.org/10.1038/s41467-019-10894-7
collection DOAJ
language English
format Article
sources DOAJ
author Oscar Ortega-Recalde
Robert C. Day
Neil J. Gemmell
Timothy A. Hore
spellingShingle Oscar Ortega-Recalde
Robert C. Day
Neil J. Gemmell
Timothy A. Hore
Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
Nature Communications
author_facet Oscar Ortega-Recalde
Robert C. Day
Neil J. Gemmell
Timothy A. Hore
author_sort Oscar Ortega-Recalde
title Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_short Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_full Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_fullStr Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_full_unstemmed Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_sort zebrafish preserve global germline dna methylation while sex-linked rdna is amplified and demethylated during feminisation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.
url https://doi.org/10.1038/s41467-019-10894-7
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AT robertcday zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation
AT neiljgemmell zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation
AT timothyahore zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation
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