First Description of Colistin and Tigecycline-Resistant <i>Acinetobacter baumannii</i> Producing KPC-3 Carbapenemase in Portugal

• Main Authors: Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte
• Format: Article
• Language: English
• Published: MDPI AG 2018-11-01
• Series: Antibiotics
• Subjects: antimicrobial resistance; Gram-negative bacteria; <i>K. pneumoniae</i>; <i>A. baumannii</i>; KPC-3 carbapenemase; colistin; tigecycline
• Online Access: https://www.mdpi.com/2079-6382/7/4/96

Herein, we describe a case report of carbapenem-resistant <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i> isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes <i>bla</i>_KPC-3, <i>bla</i>_TEM-1 and <i>bla</i>_SHV-1 in both isolates. The KPC-3 <i>K. pneumoniae</i> isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the <i>A. baumannii</i> KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.