The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults
This study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in non- diabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National...
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doaj-931981cb46ed456d9cff5070dcd6b9402020-11-25T02:44:57ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442288-16622020-09-0152316517110.15324/kjcls.2020.52.3.165The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean AdultsHyung Rag Kim0https://orcid.org/0000-0002-8473-7776Department of Laboratory Medicine, St. Galloro Hospital, Suncheon, KoreaThis study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in non- diabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents the national data in Korea. The present study had several key findings. First, in terms of HOMA-IR, after adjusting for the related variables (Model 4), the HOMA-IR (M±SE, 95% confidence interval [CI]) in group 1 (G1; estimated glomerular filtration rate [eGFR], ≥90 mL/min/1.73 m2), group 2 (G2; eGFR, 60∼89 mL/min/1.73 m2), group 3a (G3a; eGFR, 30∼59 mL/min/1.73 m2), and ≥group 3b (≥G3b; eGFR, <30 mL/min/1.73 m2) were 1.78±0.03 (1.73∼1.83), 1.87±0.03 (1.81∼1.93), 2.16±0.13 (1.91∼2.42), and 2.59±0.24 (2.12∼3.06), respectively. The HOMA-IR was positively associated with the progression of CKD (P<0.001). Second, in terms of the HOMA-B, after adjusting for the related variables (Model 4), the HOMA-B (M±SE, 95% CI) in G1, G2, G3a, and ≥G3b were 87.46±1.21 (85.08∼89.84), 89.11±1.38 (86.40∼91.81), 104.82±5.91 (93.23∼116.42), and 123.97±10.87 (102.66∼145.29), respectively. HOMA-B was positively associated with the progression of CKD (P<0.001). Both insulin resistance and the beta-cell function were positively associated with CKD in non-diabetic Korean adults.beta cell functionchronic kidney diseaseinsulin resistancenon-diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyung Rag Kim |
spellingShingle |
Hyung Rag Kim The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults Korean Journal of Clinical Laboratory Science beta cell function chronic kidney disease insulin resistance non-diabetes |
author_facet |
Hyung Rag Kim |
author_sort |
Hyung Rag Kim |
title |
The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults |
title_short |
The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults |
title_full |
The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults |
title_fullStr |
The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults |
title_full_unstemmed |
The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults |
title_sort |
relationship between the progression of chronic kidney disease and beta cell function in non-diabetic korean adults |
publisher |
The Korean Society for Clinical Laboratory Science |
series |
Korean Journal of Clinical Laboratory Science |
issn |
1738-3544 2288-1662 |
publishDate |
2020-09-01 |
description |
This study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in non- diabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents the national data in Korea. The present study had several key findings. First, in terms of HOMA-IR, after adjusting for the related variables (Model 4), the HOMA-IR (M±SE, 95% confidence interval [CI]) in group 1 (G1; estimated glomerular filtration rate [eGFR], ≥90 mL/min/1.73 m2), group 2 (G2; eGFR, 60∼89 mL/min/1.73 m2), group 3a (G3a; eGFR, 30∼59 mL/min/1.73 m2), and ≥group 3b (≥G3b; eGFR, <30 mL/min/1.73 m2) were 1.78±0.03 (1.73∼1.83), 1.87±0.03 (1.81∼1.93), 2.16±0.13 (1.91∼2.42), and 2.59±0.24 (2.12∼3.06), respectively. The HOMA-IR was positively associated with the progression of CKD (P<0.001). Second, in terms of the HOMA-B, after adjusting for the related variables (Model 4), the HOMA-B (M±SE, 95% CI) in G1, G2, G3a, and ≥G3b were 87.46±1.21 (85.08∼89.84), 89.11±1.38 (86.40∼91.81), 104.82±5.91 (93.23∼116.42), and 123.97±10.87 (102.66∼145.29), respectively. HOMA-B was positively associated with the progression of CKD (P<0.001). Both insulin resistance and the beta-cell function were positively associated with CKD in non-diabetic Korean adults. |
topic |
beta cell function chronic kidney disease insulin resistance non-diabetes |
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