Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis
Abstract Background Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiation of malignant and benign hepatic lesions. Methods PubMed, Embase, Web...
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doaj-931dea67137344229620426191be289a2020-11-25T03:50:58ZengBMCBMC Gastroenterology1471-230X2019-04-0119111210.1186/s12876-019-0976-2Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysisXing Hu0Xiaojie Huang1Hui Chen2Tong Zhang3Jianhua Hou4Aixin Song5Lei Ding6Weiyuan Liu7Hao Wu8Fankun Meng9Ultrasound and Functional Diagnosis Center, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversitySchool of Biomedical Engineering, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityUltrasound and Functional Diagnosis Center, Beijing Youan Hospital, Capital Medical UniversityUltrasound and Functional Diagnosis Center, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityUltrasound and Functional Diagnosis Center, Beijing Youan Hospital, Capital Medical UniversityAbstract Background Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiation of malignant and benign hepatic lesions. Methods PubMed, Embase, Web of Science, and the Cochrane Library were systematically reviewed to search for studies published between January 1, 1990, and November 30, 2018. The studies published in English relating to the evaluation the diagnostic accuracy of SWE imaging for distinguishing malignant and benign liver lesions were retrieved and examined for pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratios, using bivariate random-effects models. The hierarchical summary receiver operating characteristic (HSROC) curve was estimated to assess the SWE imaging accuracy. The clinical utility of SWE imaging for differentiation of malignant liver lesions was evaluated by Fagan plot. Results A total of 15 studies, involving 1894 liver lesions in 1728 patients, were eligible for the meta-analysis. The pooled sensitivity and specificity for identification of malignant liver lesions were 0.82 (95% CI: 0.77–0.86) and 0.82 (95% CI: 0.76–0.87), respectively. The AUC was 0.89 (95% CI: 0.86–0.91). When the pre-test probability was 50%, after SWE imaging measurement over the cut-off value (positive result), the corresponding post-test probability for the presence of malignant liver lesions was 82%; the post-test probability was 18% after negative measurement. Conclusions SWE imaging showed high sensitivity and specificity in differentiating malignant and benign liver lesions and may be promising for noninvasive evaluation of liver lesions. Trial registration The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42018104510.http://link.springer.com/article/10.1186/s12876-019-0976-2Liver neoplasmsUltrasonographyElasticity imaging techniquesDiagnosisMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xing Hu Xiaojie Huang Hui Chen Tong Zhang Jianhua Hou Aixin Song Lei Ding Weiyuan Liu Hao Wu Fankun Meng |
spellingShingle |
Xing Hu Xiaojie Huang Hui Chen Tong Zhang Jianhua Hou Aixin Song Lei Ding Weiyuan Liu Hao Wu Fankun Meng Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis BMC Gastroenterology Liver neoplasms Ultrasonography Elasticity imaging techniques Diagnosis Meta-analysis |
author_facet |
Xing Hu Xiaojie Huang Hui Chen Tong Zhang Jianhua Hou Aixin Song Lei Ding Weiyuan Liu Hao Wu Fankun Meng |
author_sort |
Xing Hu |
title |
Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
title_short |
Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
title_full |
Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
title_fullStr |
Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
title_full_unstemmed |
Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
title_sort |
diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2019-04-01 |
description |
Abstract Background Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiation of malignant and benign hepatic lesions. Methods PubMed, Embase, Web of Science, and the Cochrane Library were systematically reviewed to search for studies published between January 1, 1990, and November 30, 2018. The studies published in English relating to the evaluation the diagnostic accuracy of SWE imaging for distinguishing malignant and benign liver lesions were retrieved and examined for pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratios, using bivariate random-effects models. The hierarchical summary receiver operating characteristic (HSROC) curve was estimated to assess the SWE imaging accuracy. The clinical utility of SWE imaging for differentiation of malignant liver lesions was evaluated by Fagan plot. Results A total of 15 studies, involving 1894 liver lesions in 1728 patients, were eligible for the meta-analysis. The pooled sensitivity and specificity for identification of malignant liver lesions were 0.82 (95% CI: 0.77–0.86) and 0.82 (95% CI: 0.76–0.87), respectively. The AUC was 0.89 (95% CI: 0.86–0.91). When the pre-test probability was 50%, after SWE imaging measurement over the cut-off value (positive result), the corresponding post-test probability for the presence of malignant liver lesions was 82%; the post-test probability was 18% after negative measurement. Conclusions SWE imaging showed high sensitivity and specificity in differentiating malignant and benign liver lesions and may be promising for noninvasive evaluation of liver lesions. Trial registration The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42018104510. |
topic |
Liver neoplasms Ultrasonography Elasticity imaging techniques Diagnosis Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12876-019-0976-2 |
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