Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves

• Main Authors: Badrul Alam, Fahima Akter, Nahida Parvin, Rashna Sharmin Pia, Sharmin Akter, Jesmin Chowdhury, Kazi Sifath-E-Jahan, Ekramul Haque Haque
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2013-05-01
• Series: Avicenna Journal of Phytomedicine
• Subjects: Analgesic; antioxidant; anti-inflammatory; Piper betle
• Online Access: http://ajp.mums.ac.ir/pdf_16_54cb0f98a7ee0e5768a3b2253dfac9cb.html

Objective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO-) as well as  inhibition of total ROS generation, and assessment of reducing power were used to evaluate antioxidant potential of MPBL. Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (p