Rhabdoviruses, Antiviral Defense, and SUMO Pathway
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (S...
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doaj-9352f89c39044b7b84a747330ca435a62020-11-24T21:23:01ZengMDPI AGViruses1999-49152018-12-01101268610.3390/v10120686v10120686Rhabdoviruses, Antiviral Defense, and SUMO PathwayFaten El Asmi0Carlos Eduardo Brantis-de-Carvalho1Danielle Blondel2Mounira K. Chelbi-Alix3INSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, FranceINSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, FranceInstitute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS UMR 9198, Université Paris-Sud, 91190 Gif-sur-Yvette, FranceINSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, FranceSmall Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses.https://www.mdpi.com/1999-4915/10/12/686interferonrabies virusvesicular stomatitis virusIFNSUMOMxAPKR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Faten El Asmi Carlos Eduardo Brantis-de-Carvalho Danielle Blondel Mounira K. Chelbi-Alix |
spellingShingle |
Faten El Asmi Carlos Eduardo Brantis-de-Carvalho Danielle Blondel Mounira K. Chelbi-Alix Rhabdoviruses, Antiviral Defense, and SUMO Pathway Viruses interferon rabies virus vesicular stomatitis virus IFN SUMO MxA PKR |
author_facet |
Faten El Asmi Carlos Eduardo Brantis-de-Carvalho Danielle Blondel Mounira K. Chelbi-Alix |
author_sort |
Faten El Asmi |
title |
Rhabdoviruses, Antiviral Defense, and SUMO Pathway |
title_short |
Rhabdoviruses, Antiviral Defense, and SUMO Pathway |
title_full |
Rhabdoviruses, Antiviral Defense, and SUMO Pathway |
title_fullStr |
Rhabdoviruses, Antiviral Defense, and SUMO Pathway |
title_full_unstemmed |
Rhabdoviruses, Antiviral Defense, and SUMO Pathway |
title_sort |
rhabdoviruses, antiviral defense, and sumo pathway |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2018-12-01 |
description |
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses. |
topic |
interferon rabies virus vesicular stomatitis virus IFN SUMO MxA PKR |
url |
https://www.mdpi.com/1999-4915/10/12/686 |
work_keys_str_mv |
AT fatenelasmi rhabdovirusesantiviraldefenseandsumopathway AT carloseduardobrantisdecarvalho rhabdovirusesantiviraldefenseandsumopathway AT danielleblondel rhabdovirusesantiviraldefenseandsumopathway AT mounirakchelbialix rhabdovirusesantiviraldefenseandsumopathway |
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1725993925211062272 |