BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldin...
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2020-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-16148-1 |
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doaj-9367a3385a00407688e6ae5ad541e1f32021-05-16T11:11:54ZengNature Publishing GroupNature Communications2041-17232020-05-0111111510.1038/s41467-020-16148-1BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browningTongyu Liu0Lin Mi1Jing Xiong2Peter Orchard3Qi Yu4Lei Yu5Xu-Yun Zhao6Zhuo-Xian Meng7Stephen C. J. Parker8Jiandie D. Lin9Siming Li10Life Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganDepartment of Computational Medicine and Bioinformatics, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganDepartment of Pathology and Pathophysiology, Key Laboratory of Disease Proteomics of Zhejiang ProvinceDepartment of Computational Medicine and Bioinformatics, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganThe regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.https://doi.org/10.1038/s41467-020-16148-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li |
spellingShingle |
Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning Nature Communications |
author_facet |
Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li |
author_sort |
Tongyu Liu |
title |
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
title_short |
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
title_full |
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
title_fullStr |
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
title_full_unstemmed |
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
title_sort |
baf60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-05-01 |
description |
The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat. |
url |
https://doi.org/10.1038/s41467-020-16148-1 |
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