BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldin...

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Main Authors:	Tongyu Liu, Lin Mi, Jing Xiong, Peter Orchard, Qi Yu, Lei Yu, Xu-Yun Zhao, Zhuo-Xian Meng, Stephen C. J. Parker, Jiandie D. Lin, Siming Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16148-1

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spelling	doaj-9367a3385a00407688e6ae5ad541e1f32021-05-16T11:11:54ZengNature Publishing GroupNature Communications2041-17232020-05-0111111510.1038/s41467-020-16148-1BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browningTongyu Liu0Lin Mi1Jing Xiong2Peter Orchard3Qi Yu4Lei Yu5Xu-Yun Zhao6Zhuo-Xian Meng7Stephen C. J. Parker8Jiandie D. Lin9Siming Li10Life Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganDepartment of Computational Medicine and Bioinformatics, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganDepartment of Pathology and Pathophysiology, Key Laboratory of Disease Proteomics of Zhejiang ProvinceDepartment of Computational Medicine and Bioinformatics, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganLife Sciences Institute and Department of Cell and Developmental Biology, University of MichiganThe regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.https://doi.org/10.1038/s41467-020-16148-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li
spellingShingle	Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning Nature Communications
author_facet	Tongyu Liu Lin Mi Jing Xiong Peter Orchard Qi Yu Lei Yu Xu-Yun Zhao Zhuo-Xian Meng Stephen C. J. Parker Jiandie D. Lin Siming Li
author_sort	Tongyu Liu
title	BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
title_short	BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
title_full	BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
title_fullStr	BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
title_full_unstemmed	BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
title_sort	baf60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.
url	https://doi.org/10.1038/s41467-020-16148-1
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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

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