Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey
Introduction: Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people. This study aimed to explore the nonlinear relationship between SUA levels and hypertension in Han and...
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2021-09-01
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doaj-9368933dc34d451f86c68ad58f5920bb2021-10-07T13:44:27ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432021-09-0111110.1159/000518768518768Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health SurveyChengdong Yu0Xiaolan Ren1Li Pan2Hongjun Zhao3Ye Wang4Lijun Chang5Huijing He6Jin’en Xi7Guangliang Shan8Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaInstitute of Chronic and Noncommunicable Disease Control and Prevention, Gansu Provincial Centre for Disease Control and Prevention, Lanzhou, ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaInstitute of Chronic and Noncommunicable Disease Control and Prevention, Gansu Provincial Centre for Disease Control and Prevention, Lanzhou, ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaInstitute of Chronic and Noncommunicable Disease Control and Prevention, Gansu Provincial Centre for Disease Control and Prevention, Lanzhou, ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaInstitute of Chronic and Noncommunicable Disease Control and Prevention, Gansu Provincial Centre for Disease Control and Prevention, Lanzhou, ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaIntroduction: Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people. This study aimed to explore the nonlinear relationship between SUA levels and hypertension in Han and Yugur people in China. Methods: The cross-sectional study samples (n = 5,327) were from the China National Health Survey (CNHS) in Gansu Province. Participants were selected using a multistage stratified cluster sampling method. SUA was measured by enzymatic methods. The restricted cubic spline regression was performed to evaluate the shape of the association. Results: The overall prevalence of hypertension and hyperuricemia was 28.4% and 17.0%, respectively, in this study. Comparing the highest (>416.4 μmol/L) to the lowest (<254.1 μmol/L) SUA level groups, the multivariable adjusted differences and 95% confidence intervals (CIs) in blood pressure (BP) were 6.15 (4.22, 8.08) mm Hg and 4.87 (3.51, 6.23) mm Hg for SBP and DBP in Han, and 2.22 (−0.73, 5.18) mm Hg and 2.56 (0.38, 4.75) mm Hg for SBP and DBP in Yugur people, respectively. The corresponding odds ratios (95% CIs) for hypertension were 3.16 (2.26, 4.43) and 2.37 (1.46, 3.89) in Han and Yugur people, respectively. The restricted cubic spline regression models illustrated that both BP level and the risk of hypertension increased with elevated SUA levels in Han and Yugur people. Conclusions: SUA was significantly and independently associated with an increased risk of hypertension in Han and Yugur people. Prospective studies are needed to confirm these findings.https://www.karger.com/Article/FullText/518768serum uric acidblood pressurehypertensionyugur peoplechina national health survey |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chengdong Yu Xiaolan Ren Li Pan Hongjun Zhao Ye Wang Lijun Chang Huijing He Jin’en Xi Guangliang Shan |
spellingShingle |
Chengdong Yu Xiaolan Ren Li Pan Hongjun Zhao Ye Wang Lijun Chang Huijing He Jin’en Xi Guangliang Shan Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey Kidney & Blood Pressure Research serum uric acid blood pressure hypertension yugur people china national health survey |
author_facet |
Chengdong Yu Xiaolan Ren Li Pan Hongjun Zhao Ye Wang Lijun Chang Huijing He Jin’en Xi Guangliang Shan |
author_sort |
Chengdong Yu |
title |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey |
title_short |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey |
title_full |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey |
title_fullStr |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey |
title_full_unstemmed |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey |
title_sort |
association between serum uric acid and hypertension in han and yugur of gansu province: the china national health survey |
publisher |
Karger Publishers |
series |
Kidney & Blood Pressure Research |
issn |
1420-4096 1423-0143 |
publishDate |
2021-09-01 |
description |
Introduction: Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people. This study aimed to explore the nonlinear relationship between SUA levels and hypertension in Han and Yugur people in China. Methods: The cross-sectional study samples (n = 5,327) were from the China National Health Survey (CNHS) in Gansu Province. Participants were selected using a multistage stratified cluster sampling method. SUA was measured by enzymatic methods. The restricted cubic spline regression was performed to evaluate the shape of the association. Results: The overall prevalence of hypertension and hyperuricemia was 28.4% and 17.0%, respectively, in this study. Comparing the highest (>416.4 μmol/L) to the lowest (<254.1 μmol/L) SUA level groups, the multivariable adjusted differences and 95% confidence intervals (CIs) in blood pressure (BP) were 6.15 (4.22, 8.08) mm Hg and 4.87 (3.51, 6.23) mm Hg for SBP and DBP in Han, and 2.22 (−0.73, 5.18) mm Hg and 2.56 (0.38, 4.75) mm Hg for SBP and DBP in Yugur people, respectively. The corresponding odds ratios (95% CIs) for hypertension were 3.16 (2.26, 4.43) and 2.37 (1.46, 3.89) in Han and Yugur people, respectively. The restricted cubic spline regression models illustrated that both BP level and the risk of hypertension increased with elevated SUA levels in Han and Yugur people. Conclusions: SUA was significantly and independently associated with an increased risk of hypertension in Han and Yugur people. Prospective studies are needed to confirm these findings. |
topic |
serum uric acid blood pressure hypertension yugur people china national health survey |
url |
https://www.karger.com/Article/FullText/518768 |
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