Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line

Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line

Lung cancer, among all cancer types around the world, is listed as the major cause of death with high mortality rate. ERG transcription factor has an important role in the Epithelial Mesenchymal Transition (EMT), which is one of the most important mechanisms in lung cancer progression. It is known t...

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Bibliographic Details
Main Authors: Sara Alkhatib, Emine Kandemiş, Gamze Gizir, Gülay Bulut
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Proceedings
Subjects:
lung cancer
ERG
EMT
YK-4-279
paclitaxel
synergistic effect
Online Access:https://www.mdpi.com/2504-3900/2/25/1588
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spelling doaj-936f7e30d74747d895c572f8d5c7769a2020-11-25T01:40:47ZengMDPI AGProceedings2504-39002018-12-01225158810.3390/proceedings2251588proceedings2251588Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell LineSara Alkhatib0Emine Kandemiş1Gamze Gizir2Gülay Bulut3Bioengineering Program, Graduate School of Natural and Applied Sciences, Bahçeşehir University, 34353 Istanbul, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahçeşehir University, 34353 Istanbul, TurkeyBioengineering Program, Graduate School of Natural and Applied Sciences, Bahçeşehir University, 34353 Istanbul, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahçeşehir University, 34353 Istanbul, TurkeyLung cancer, among all cancer types around the world, is listed as the major cause of death with high mortality rate. ERG transcription factor has an important role in the Epithelial Mesenchymal Transition (EMT), which is one of the most important mechanisms in lung cancer progression. It is known that a small molecule inhibitor YK-4-279 is a potential inhibitor of ERG expression in prostate cancer. In this study, the possible synergistic effect of YK-4-279 and another anticancer drug, Paclitaxel is analysed in non-small cell lung cancer (NSCLC) cell line, A549.https://www.mdpi.com/2504-3900/2/25/1588lung cancerERGEMTYK-4-279paclitaxelsynergistic effect
collection DOAJ
language English
format Article
sources DOAJ
author Sara Alkhatib
Emine Kandemiş
Gamze Gizir
Gülay Bulut
spellingShingle Sara Alkhatib
Emine Kandemiş
Gamze Gizir
Gülay Bulut
Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
Proceedings
lung cancer
ERG
EMT
YK-4-279
paclitaxel
synergistic effect
author_facet Sara Alkhatib
Emine Kandemiş
Gamze Gizir
Gülay Bulut
author_sort Sara Alkhatib
title Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
title_short Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
title_full Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
title_fullStr Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
title_full_unstemmed Synergistic Effect of YK-4-279 and Paclitaxel on A549 Cell Line
title_sort synergistic effect of yk-4-279 and paclitaxel on a549 cell line
publisher MDPI AG
series Proceedings
issn 2504-3900
publishDate 2018-12-01
description Lung cancer, among all cancer types around the world, is listed as the major cause of death with high mortality rate. ERG transcription factor has an important role in the Epithelial Mesenchymal Transition (EMT), which is one of the most important mechanisms in lung cancer progression. It is known that a small molecule inhibitor YK-4-279 is a potential inhibitor of ERG expression in prostate cancer. In this study, the possible synergistic effect of YK-4-279 and another anticancer drug, Paclitaxel is analysed in non-small cell lung cancer (NSCLC) cell line, A549.
topic lung cancer
ERG
EMT
YK-4-279
paclitaxel
synergistic effect
url https://www.mdpi.com/2504-3900/2/25/1588
work_keys_str_mv AT saraalkhatib synergisticeffectofyk4279andpaclitaxelona549cellline
AT eminekandemis synergisticeffectofyk4279andpaclitaxelona549cellline
AT gamzegizir synergisticeffectofyk4279andpaclitaxelona549cellline
AT gulaybulut synergisticeffectofyk4279andpaclitaxelona549cellline
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