Review of the mechanism of biomimetic intrafibrillar mineralization

• Main Authors: NIU Lina, CHEN Jihua, JIAO Kai
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2018-06-01
• Series: 口腔疾病防治
• Subjects: Biomimetic mineralization; Non⁃collagenous protein; Intrafibrillar mineralization; Amorphous calcium phosphate; Pre⁃nucleation cluster
• Online Access: http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2018.06.002

Bone is a hierarchically structured and highly mineralized hard tissue composed of an organic phase (type I collagen and noncollagenous proteins) and an inorganic phase (nanohydroxyapatite). Intrafibrillar mineralized col⁃ lagen is the basic structural unit of bone tissue and is of high significance due to its superior mechanical and biological properties. Thus, to truly understand the unique properties of bone, it is necessary to review the most basic structural level of bone. In this article, we review the recent advances in understanding the development of intrafibrillar mineral⁃ ization and the prevailing theories in the formation of such intrafibrillar minerals. Understanding the mechanisms of in⁃ trafibrillar mineralization may facilitate the development of engineered bone for clinical applications and provide deeper insight into the nature of biomineralization.