Advances in the Management of HPV-Related Oropharyngeal Cancer

Advances in the Management of HPV-Related Oropharyngeal Cancer

Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approache...

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Main Authors: F. De Felice, V. Tombolini, V. Valentini, M. de Vincentiis, S. Mezi, O. Brugnoletti, A. Polimeni
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2019/9173729
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spelling doaj-938cda86ce1f41a893bd82ed757c9f0a2020-11-24T21:51:05ZengHindawi LimitedJournal of Oncology1687-84501687-84692019-01-01201910.1155/2019/91737299173729Advances in the Management of HPV-Related Oropharyngeal CancerF. De Felice0V. Tombolini1V. Valentini2M. de Vincentiis3S. Mezi4O. Brugnoletti5A. Polimeni6Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyDepartment of Medical Oncology, Policlinico Umberto I “Sapienza” University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyPatients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients.http://dx.doi.org/10.1155/2019/9173729
collection DOAJ
language English
format Article
sources DOAJ
author F. De Felice
V. Tombolini
V. Valentini
M. de Vincentiis
S. Mezi
O. Brugnoletti
A. Polimeni
spellingShingle F. De Felice
V. Tombolini
V. Valentini
M. de Vincentiis
S. Mezi
O. Brugnoletti
A. Polimeni
Advances in the Management of HPV-Related Oropharyngeal Cancer
Journal of Oncology
author_facet F. De Felice
V. Tombolini
V. Valentini
M. de Vincentiis
S. Mezi
O. Brugnoletti
A. Polimeni
author_sort F. De Felice
title Advances in the Management of HPV-Related Oropharyngeal Cancer
title_short Advances in the Management of HPV-Related Oropharyngeal Cancer
title_full Advances in the Management of HPV-Related Oropharyngeal Cancer
title_fullStr Advances in the Management of HPV-Related Oropharyngeal Cancer
title_full_unstemmed Advances in the Management of HPV-Related Oropharyngeal Cancer
title_sort advances in the management of hpv-related oropharyngeal cancer
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2019-01-01
description Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients.
url http://dx.doi.org/10.1155/2019/9173729
work_keys_str_mv AT fdefelice advancesinthemanagementofhpvrelatedoropharyngealcancer
AT vtombolini advancesinthemanagementofhpvrelatedoropharyngealcancer
AT vvalentini advancesinthemanagementofhpvrelatedoropharyngealcancer
AT mdevincentiis advancesinthemanagementofhpvrelatedoropharyngealcancer
AT smezi advancesinthemanagementofhpvrelatedoropharyngealcancer
AT obrugnoletti advancesinthemanagementofhpvrelatedoropharyngealcancer
AT apolimeni advancesinthemanagementofhpvrelatedoropharyngealcancer
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