Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis
Abstract Background There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been published, but so far with conflicting results. Methods A systematic rev...
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doaj-9394defb00994c2c8a828e17447109c72021-09-12T11:51:41ZengBMCReproductive Biology and Endocrinology1477-78272021-09-0119111710.1186/s12958-021-00809-xAssociation between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysisJiaqi Yang0Yichen He1Yiqing Wu2Dan Zhang3Hefeng Huang4Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Zhejiang University, School of Medicine, Women’s HospitalInternational Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Zhejiang University, School of Medicine, Women’s HospitalKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Zhejiang University, School of Medicine, Women’s HospitalKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Zhejiang University, School of Medicine, Women’s HospitalAbstract Background There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been published, but so far with conflicting results. Methods A systematic review and meta-analysis was conducted according to PRISMA guidelines. Pubmed, Embase, Cochrane Library, Clinicaltrails.gov and Web of Science databases were searched based on established search strategy from inception through January 2021. Results Twelve studies were eligible. In women following FET, high BMI (BMI ≥ 23 kg/m2) was associated with an impaired live birth rate (LBR, OR: 0.89, 95% CI: 0.82–0.96, P = 0.002), but wasn’t associated with the implantation rate or the clinical pregnancy rate. Subgroup analysis revealed higher LBR for women didn’t complicated by polycystic ovary syndrome (PCOS, OR: 0.96, 95% CI: 0.85–1.08, P = 0.46) and women with blastocyst transferred (OR: 0.89, 95% CI: 0.68–1.16, P = 0.40). LBR did not differ between the low BMI group (BMI < 18.5 kg/m2) and the normal weight group. Conclusions Our study showed that high BMI in women is negatively associated with LBR in FET cycles, whereas low BMI isn’t. The results of subgroup analysis implied a need for women with a high BMI to get individualized weight management and treatment. Further evidence is still required to optimize preconception health and develop Nutritional and exercise guidelines.https://doi.org/10.1186/s12958-021-00809-xFETBMILive birth rateARTMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiaqi Yang Yichen He Yiqing Wu Dan Zhang Hefeng Huang |
spellingShingle |
Jiaqi Yang Yichen He Yiqing Wu Dan Zhang Hefeng Huang Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis Reproductive Biology and Endocrinology FET BMI Live birth rate ART Meta-analysis |
author_facet |
Jiaqi Yang Yichen He Yiqing Wu Dan Zhang Hefeng Huang |
author_sort |
Jiaqi Yang |
title |
Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
title_short |
Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
title_full |
Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
title_fullStr |
Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
title_full_unstemmed |
Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
title_sort |
association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis |
publisher |
BMC |
series |
Reproductive Biology and Endocrinology |
issn |
1477-7827 |
publishDate |
2021-09-01 |
description |
Abstract Background There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been published, but so far with conflicting results. Methods A systematic review and meta-analysis was conducted according to PRISMA guidelines. Pubmed, Embase, Cochrane Library, Clinicaltrails.gov and Web of Science databases were searched based on established search strategy from inception through January 2021. Results Twelve studies were eligible. In women following FET, high BMI (BMI ≥ 23 kg/m2) was associated with an impaired live birth rate (LBR, OR: 0.89, 95% CI: 0.82–0.96, P = 0.002), but wasn’t associated with the implantation rate or the clinical pregnancy rate. Subgroup analysis revealed higher LBR for women didn’t complicated by polycystic ovary syndrome (PCOS, OR: 0.96, 95% CI: 0.85–1.08, P = 0.46) and women with blastocyst transferred (OR: 0.89, 95% CI: 0.68–1.16, P = 0.40). LBR did not differ between the low BMI group (BMI < 18.5 kg/m2) and the normal weight group. Conclusions Our study showed that high BMI in women is negatively associated with LBR in FET cycles, whereas low BMI isn’t. The results of subgroup analysis implied a need for women with a high BMI to get individualized weight management and treatment. Further evidence is still required to optimize preconception health and develop Nutritional and exercise guidelines. |
topic |
FET BMI Live birth rate ART Meta-analysis |
url |
https://doi.org/10.1186/s12958-021-00809-x |
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