Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules
Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature.CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiar...
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doaj-9395ec7de72744a8a0c33401a9cab9e32021-03-19T07:03:35ZengElsevierCatalysis Communications1873-39052021-01-01149106211Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug moleculesFirouz Matloubi Moghaddam0Raheleh Pourkaveh1Mahdi Heidarian2Corresponding author.; Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Azadi Street, PO Box 111559516, Tehran, IranLaboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Azadi Street, PO Box 111559516, Tehran, IranLaboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Azadi Street, PO Box 111559516, Tehran, IranOxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature.CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity.http://www.sciencedirect.com/science/article/pii/S1566736720302879α-Aminonitrilesp3C–H activationCobalt copper ferriteRoom temperature |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Firouz Matloubi Moghaddam Raheleh Pourkaveh Mahdi Heidarian |
spellingShingle |
Firouz Matloubi Moghaddam Raheleh Pourkaveh Mahdi Heidarian Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules Catalysis Communications α-Aminonitrile sp3C–H activation Cobalt copper ferrite Room temperature |
author_facet |
Firouz Matloubi Moghaddam Raheleh Pourkaveh Mahdi Heidarian |
author_sort |
Firouz Matloubi Moghaddam |
title |
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules |
title_short |
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules |
title_full |
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules |
title_fullStr |
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules |
title_full_unstemmed |
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules |
title_sort |
nano cobalt-copper ferrite catalyzed regioselective α-c(sp3)–h cyanation of amines: secondary, tertiary, and drug molecules |
publisher |
Elsevier |
series |
Catalysis Communications |
issn |
1873-3905 |
publishDate |
2021-01-01 |
description |
Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature.CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity. |
topic |
α-Aminonitrile sp3C–H activation Cobalt copper ferrite Room temperature |
url |
http://www.sciencedirect.com/science/article/pii/S1566736720302879 |
work_keys_str_mv |
AT firouzmatloubimoghaddam nanocobaltcopperferritecatalyzedregioselectiveacsp3hcyanationofaminessecondarytertiaryanddrugmolecules AT rahelehpourkaveh nanocobaltcopperferritecatalyzedregioselectiveacsp3hcyanationofaminessecondarytertiaryanddrugmolecules AT mahdiheidarian nanocobaltcopperferritecatalyzedregioselectiveacsp3hcyanationofaminessecondarytertiaryanddrugmolecules |
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