P97 FAMILY PATTERNS OF CENTRAL HAEMODYNAMICS ACROSS THREE GENERATIONS IN THE MALMö OFFSPRING STUDY

• Main Authors: Peter Nilsson, Erik Petersson Rosberg
• Format: Article
• Language: English
• Published: Atlantis Press 2018-12-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930101/view

Background: Markers of central haemodynamics have in recent years emerged as promising predictors of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and affect organs directly attached to large arteries. Carotid-Femoral pulse wave velocity (c-f PWV), Augmentation index (Aix), and central systolic blood pressure (cSBP) are variables from indirect measurements that reflect central haemodynamic and arterial stiffness. Family patterns exist [1]. Aim: To investigate if a relationship exists for patterns of central haemodynamics across three related generations, especially c-f PWV. Methods: In all, 1131 participants from Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included in this study. c-f PWV was measured in grandparents and in all offspring. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were divided in quartiles by c-f PWV and offspring c-f PWV, and cSBP means were compared with one-way ANOVA analyses. Multiple regression analyses were conducted to adjust for age, sex, BMI, SBP and fasting glucose. Results: c-f PWV in grandchildren was positively correlated with c-f PWV in parents (r = 0.26, p < 0.001) and in grandparents (r = 0.29, p < 0.001). Offspring c-f PWV correlated significantly with parental Aix and cSBP. Parents with high c-f PWV had offspring with statistically significant higher means of c-f PWV and cSBP than parents with low c-f PWV. Conclusion: Measures of central haemodynamic are positively correlated across three generations in a population-based study.