Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families
Objective. Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to...
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Online Access: | http://dx.doi.org/10.1155/2015/298506 |
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doaj-93afb7733b3146ea9ecfbddd2af1189d2020-11-25T01:02:46ZengHindawi LimitedAutoimmune Diseases2090-04222090-04302015-01-01201510.1155/2015/298506298506Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus FamiliesRachna Aggarwal0Juan-Manuel Anaya1Kristi A. Koelsch2Biji T. Kurien3R. Hal Scofield4Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USACenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, ColombiaDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAObjective. Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p=5×10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p=1×10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease.http://dx.doi.org/10.1155/2015/298506 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachna Aggarwal Juan-Manuel Anaya Kristi A. Koelsch Biji T. Kurien R. Hal Scofield |
spellingShingle |
Rachna Aggarwal Juan-Manuel Anaya Kristi A. Koelsch Biji T. Kurien R. Hal Scofield Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families Autoimmune Diseases |
author_facet |
Rachna Aggarwal Juan-Manuel Anaya Kristi A. Koelsch Biji T. Kurien R. Hal Scofield |
author_sort |
Rachna Aggarwal |
title |
Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families |
title_short |
Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families |
title_full |
Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families |
title_fullStr |
Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families |
title_full_unstemmed |
Association between Secondary and Primary Sjögren’s Syndrome in a Large Collection of Lupus Families |
title_sort |
association between secondary and primary sjögren’s syndrome in a large collection of lupus families |
publisher |
Hindawi Limited |
series |
Autoimmune Diseases |
issn |
2090-0422 2090-0430 |
publishDate |
2015-01-01 |
description |
Objective. Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p=5×10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p=1×10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease. |
url |
http://dx.doi.org/10.1155/2015/298506 |
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