A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer

A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer

Background: The Notch signal transduction pathway is pivotal for various physiological processes, including immune responses, and has been implicated in the pathogenesis of many diseases. The effectiveness of various targeted Notch pathway inhibitors may vary due to variabilities in Notch pathway ac...

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Bibliographic Details
Main Authors:	Kirsten Canté-Barrett, Laurent Holtzer, Henk van Ooijen, Rico Hagelaar, Valentina Cordo’, Wim Verhaegh, Anja van de Stolpe, Jules P. P. Meijerink
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Cancers
Subjects:	Notch pathway activity NOTCH1 mutation T cell acute lymphoblastic leukemia
Online Access:	https://www.mdpi.com/2072-6694/12/11/3142

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