Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
Abstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical...
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doaj-93be8979ea0341d99e7bb13edf20d3a02021-07-04T11:28:22ZengNature Publishing GroupScientific Reports2045-23222021-06-011111810.1038/s41598-021-93001-5Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritisNaphruet Limsakul0Praveena Chiowchanwisawakit1Parichart Permpikul2Yubolrat Thanaketpaisarn3Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical data were collected. Regression analyses were employed to identify factors associated with study outcomes. Of total 177 patients, 127 (72%) were positive HLA-B27. Uveitis [Odds ratio (OR) 4.0], age at onset of the first musculoskeletal symptom of ≤ 28 years [OR 3.5], female [OR 0.4], and psoriasis [OR 0.4] were significantly associated with HLA-B27 in multiple regression analysis. Those with positive HLA-B27 had less spinal flexibility. Elevated C-reactive protein (p = 0.012) was associated with shorter delay in diagnosis, while uveitis (p < 0.001) and younger age at onset of the first symptom (p = 0.002) were associated with longer delay in diagnosis in multiple regression analysis. Younger age at onset of the first musculoskeletal symptom and uveitis were associated with HLA-B27 and delayed diagnosis in axSpA patients. Young people with musculoskeletal symptom and uveitis should be referred to a rheumatologist to rule out or make a timely diagnosis of axSpA.https://doi.org/10.1038/s41598-021-93001-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn |
spellingShingle |
Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis Scientific Reports |
author_facet |
Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn |
author_sort |
Naphruet Limsakul |
title |
Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis |
title_short |
Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis |
title_full |
Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis |
title_fullStr |
Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis |
title_full_unstemmed |
Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis |
title_sort |
younger age of onset and uveitis associated with hla-b27 and delayed diagnosis in thai patients with axial spondyloarthritis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-06-01 |
description |
Abstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical data were collected. Regression analyses were employed to identify factors associated with study outcomes. Of total 177 patients, 127 (72%) were positive HLA-B27. Uveitis [Odds ratio (OR) 4.0], age at onset of the first musculoskeletal symptom of ≤ 28 years [OR 3.5], female [OR 0.4], and psoriasis [OR 0.4] were significantly associated with HLA-B27 in multiple regression analysis. Those with positive HLA-B27 had less spinal flexibility. Elevated C-reactive protein (p = 0.012) was associated with shorter delay in diagnosis, while uveitis (p < 0.001) and younger age at onset of the first symptom (p = 0.002) were associated with longer delay in diagnosis in multiple regression analysis. Younger age at onset of the first musculoskeletal symptom and uveitis were associated with HLA-B27 and delayed diagnosis in axSpA patients. Young people with musculoskeletal symptom and uveitis should be referred to a rheumatologist to rule out or make a timely diagnosis of axSpA. |
url |
https://doi.org/10.1038/s41598-021-93001-5 |
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