Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis
Aims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. Methods: Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year...
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2011-11-01
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doaj-93c820fdccff4b72be5c86f839168a2e2020-11-25T02:31:24ZengKarger PublishersCase Reports in Ophthalmology1663-26992011-11-012333834210.1159/000334270334270Double-Biguanide Therapy for Resistant Acanthamoeba KeratitisGiulio FerrariStanislav MatuskaPaolo RamaAims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. Methods: Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year-old woman presenting with corneal ulcer in her left eye. Results: The patient was successfully treated with PHMB-chlorhexidine association therapy. Subsequent perforating keratoplasty remained clear at the last follow-up visit after 7 months and increased visual acuity to 20/20 with correction. Conclusions: This case emphasizes the proteiform aspects of Acanthamoeba drug resistance, and suggests that PHMB-chlorhexidine association might represent an additional option for cases resistant to standard therapy.http://www.karger.com/Article/FullText/334270Acanthamoeba keratitisBiguanideDiamidine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giulio Ferrari Stanislav Matuska Paolo Rama |
spellingShingle |
Giulio Ferrari Stanislav Matuska Paolo Rama Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis Case Reports in Ophthalmology Acanthamoeba keratitis Biguanide Diamidine |
author_facet |
Giulio Ferrari Stanislav Matuska Paolo Rama |
author_sort |
Giulio Ferrari |
title |
Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis |
title_short |
Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis |
title_full |
Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis |
title_fullStr |
Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis |
title_full_unstemmed |
Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis |
title_sort |
double-biguanide therapy for resistant acanthamoeba keratitis |
publisher |
Karger Publishers |
series |
Case Reports in Ophthalmology |
issn |
1663-2699 |
publishDate |
2011-11-01 |
description |
Aims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. Methods: Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year-old woman presenting with corneal ulcer in her left eye. Results: The patient was successfully treated with PHMB-chlorhexidine association therapy. Subsequent perforating keratoplasty remained clear at the last follow-up visit after 7 months and increased visual acuity to 20/20 with correction. Conclusions: This case emphasizes the proteiform aspects of Acanthamoeba drug resistance, and suggests that PHMB-chlorhexidine association might represent an additional option for cases resistant to standard therapy. |
topic |
Acanthamoeba keratitis Biguanide Diamidine |
url |
http://www.karger.com/Article/FullText/334270 |
work_keys_str_mv |
AT giulioferrari doublebiguanidetherapyforresistantacanthamoebakeratitis AT stanislavmatuska doublebiguanidetherapyforresistantacanthamoebakeratitis AT paolorama doublebiguanidetherapyforresistantacanthamoebakeratitis |
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