Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
The rapid and persistent increase of drug-resistant Mycobacterium tuberculosis (Mtb) infections poses increasing global problems in combatting tuberculosis (TB), prompting for the development of alternative strategies including host-directed therapy (HDT). Since Mtb is an intracellular pathogen with...
Main Authors: | Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-02-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00036/full |
Similar Items
-
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
by: Giorgio Milazzo, et al.
Published: (2020-05-01) -
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
by: Darwish, S., et al.
Published: (2022) -
Histone Deacetylase 3 (HDAC3) Regulates Lymphatic Vascular Development
by: Palleti Janardhan, Harish P.
Published: (2018) -
Regulating the Regulators: The Role of Histone Deacetylase 1 (HDAC1) in Erythropoiesis
by: Min Young Kim, et al.
Published: (2020-11-01) -
HDAC3 and HDAC8 are required for cilia assembly and elongation
by: Seon-ah Park, et al.
Published: (2019-08-01)