Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
Abstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed pr...
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doaj-93d0c0df380a4fc8bf22050d7783da182020-11-24T21:21:05ZengUniversidad de AntioquiaVitae0121-4004241232910.17533/udea.vitae.v24n1a03S0121-40042017000100023Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine modelAna María Henao-DuqueBerardo de Jesús RodríguezJaime Andrés PereañezTatiana Lobo-EcheverriVitelbina Núñez RangelAbstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16, 23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16, 23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042017000100023&lng=en&tlng=enLeaf extractoralpathologySwietenia macrophyllatoxicology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel |
spellingShingle |
Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model Vitae Leaf extract oral pathology Swietenia macrophylla toxicology |
author_facet |
Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel |
author_sort |
Ana María Henao-Duque |
title |
Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model |
title_short |
Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model |
title_full |
Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model |
title_fullStr |
Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model |
title_full_unstemmed |
Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model |
title_sort |
acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of swietenia macrophylla king in a murine model |
publisher |
Universidad de Antioquia |
series |
Vitae |
issn |
0121-4004 |
description |
Abstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16, 23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16, 23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low. |
topic |
Leaf extract oral pathology Swietenia macrophylla toxicology |
url |
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042017000100023&lng=en&tlng=en |
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