Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes with biacetyl-derived Schiff bases

• Main Authors: MUHAMMAD IMRAN, LIVIU MITU, SHOOMAILA LATIF, ZAID MAHMOOD, IMTIAZ NAIMAT, SANA S. ZAMAN, SURRYA FATIMA
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2010-08-01
• Series: Journal of the Serbian Chemical Society
• Subjects: Schiff base; biacetyl; metal ion; antibacterial activity
• Online Access: http://www.shd.org.rs/JSCS/Vol75/No8/06_4600_4032.pdf

The condensation reactions of biacetyl with ortho-hydroxyaniline and 2-aminobenzoic acid to form bidendate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2(H2O)2] where M = Co(II), Ni(II), Cu(II) and Zn(II) and L = HL1 and HL2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, and IR, 1H-NMR, 13C-NMR and electronic spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141–160 °C. These compounds were also screened for their in vitro antibacterial activity against four bacterial species, namely: Escherichia coli, Staphylococcus aureus, Salmonella typhi and Bacillus subtilis. The metal complexes were found to have greater antibacterial activity than the uncomplexed Schiff base ligands.