A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced Nephrotoxicity

A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced Nephrotoxicity

Fast tacrolimus metabolism is linked to inferior outcomes such as rejection and lower renal function after kidney transplantation. Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy. The present contribution hypothesized that tacrolimus-induced nephrotoxicity is re...

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Bibliographic Details
Main Authors: Gerold Thölking, Katharina Schütte-Nütgen, Julia Schmitz, Alexandros Rovas, Maximilian Dahmen, Joachim Bautz, Ulrich Jehn, Hermann Pavenstädt, Barbara Heitplatz, Veerle Van Marck, Barbara Suwelack, Stefan Reuter
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
calcineurin inhibitor nephrotoxcity
tacrolimus
c/d ratio
tacrolimus metabolism
kidney transplantation
Online Access:https://www.mdpi.com/2077-0383/8/10/1586

Internet

https://www.mdpi.com/2077-0383/8/10/1586

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