Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were...
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doaj-93dadb5bf7ea44f1a388f513791159f22020-11-25T02:10:12ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162019-01-01571374710.1080/13880209.2018.15649301564930Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoproteinAbdullah S. Shatoor0Suliman Al Humayed1Mahmoud A. Alkhateeb2Khalid A. Shatoor3Hussain Aldera4Mohammed Alassiri5Ali A. Shati6Cardiology Section, College of Medicine, King Khalid University (KKU)Cardiology Section, College of Medicine, King Khalid University (KKU)College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)An intern, College of Medicine, King Khalid University (KKU)College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)College of Medicine, King Khalid University (KKU)Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks. Results: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments. Conclusions: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended.http://dx.doi.org/10.1080/13880209.2018.1564930hyperlipidemiaatherosclerosisaortaoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdullah S. Shatoor Suliman Al Humayed Mahmoud A. Alkhateeb Khalid A. Shatoor Hussain Aldera Mohammed Alassiri Ali A. Shati |
spellingShingle |
Abdullah S. Shatoor Suliman Al Humayed Mahmoud A. Alkhateeb Khalid A. Shatoor Hussain Aldera Mohammed Alassiri Ali A. Shati Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein Pharmaceutical Biology hyperlipidemia atherosclerosis aorta oxidative stress |
author_facet |
Abdullah S. Shatoor Suliman Al Humayed Mahmoud A. Alkhateeb Khalid A. Shatoor Hussain Aldera Mohammed Alassiri Ali A. Shati |
author_sort |
Abdullah S. Shatoor |
title |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
title_short |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
title_full |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
title_fullStr |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
title_full_unstemmed |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
title_sort |
crataegus aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein |
publisher |
Taylor & Francis Group |
series |
Pharmaceutical Biology |
issn |
1388-0209 1744-5116 |
publishDate |
2019-01-01 |
description |
Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks. Results: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments. Conclusions: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended. |
topic |
hyperlipidemia atherosclerosis aorta oxidative stress |
url |
http://dx.doi.org/10.1080/13880209.2018.1564930 |
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