Mammalian γ2 AMPK regulates intrinsic heart rate
AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive b...
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Format: | Article |
Language: | English |
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Nature Publishing Group
2017-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01342-5 |
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doaj-93dc1bb6f94248b0bbd5f23512479816 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian |
spellingShingle |
Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian Mammalian γ2 AMPK regulates intrinsic heart rate Nature Communications |
author_facet |
Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian |
author_sort |
Arash Yavari |
title |
Mammalian γ2 AMPK regulates intrinsic heart rate |
title_short |
Mammalian γ2 AMPK regulates intrinsic heart rate |
title_full |
Mammalian γ2 AMPK regulates intrinsic heart rate |
title_fullStr |
Mammalian γ2 AMPK regulates intrinsic heart rate |
title_full_unstemmed |
Mammalian γ2 AMPK regulates intrinsic heart rate |
title_sort |
mammalian γ2 ampk regulates intrinsic heart rate |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-11-01 |
description |
AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice. |
url |
https://doi.org/10.1038/s41467-017-01342-5 |
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doaj-93dc1bb6f94248b0bbd5f235124798162021-05-11T07:56:04ZengNature Publishing GroupNature Communications2041-17232017-11-018111910.1038/s41467-017-01342-5Mammalian γ2 AMPK regulates intrinsic heart rateArash Yavari0Mohamed Bellahcene1Annalisa Bucchi2Syevda Sirenko3Katalin Pinter4Neil Herring5Julia J. Jung6Kirill V. Tarasov7Emily J. Sharpe8Markus Wolfien9Gabor Czibik10Violetta Steeples11Sahar Ghaffari12Chinh Nguyen13Alexander Stockenhuber14Joshua R. St. Clair15Christian Rimmbach16Yosuke Okamoto17Dongmei Yang18Mingyi Wang19Bruce D. Ziman20Jack M. Moen21Daniel R. Riordon22Christopher Ramirez23Manuel Paina24Joonho Lee25Jing Zhang26Ismayil Ahmet27Michael G. Matt28Yelena S. Tarasova29Dilair Baban30Natasha Sahgal31Helen Lockstone32Rathi Puliyadi33Joseph de Bono34Owen M. Siggs35John Gomes36Hannah Muskett37Mahon L. Maguire38Youlia Beglov39Matthew Kelly40Pedro P. N. dos Santos41Nicola J. Bright42Angela Woods43Katja Gehmlich44Henrik Isackson45Gillian Douglas46David J. P. Ferguson47Jürgen E. Schneider48Andrew Tinker49Olaf Wolkenhauer50Keith M. Channon51Richard J. Cornall52Eduardo B. Sternick53David J. Paterson54Charles S. Redwood55David Carling56Catherine Proenza57Robert David58Mirko Baruscotti59Dario DiFrancesco60Edward G. Lakatta61Hugh Watkins62Houman Ashrafian63Experimental Therapeutics, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDepartment of Biosciences, Università degli Studi di MilanoLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of OxfordDepartment of Cardiac Surgery, Rostock University Medical CentreLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHDepartment of Physiology and Biophysics, University of Colorado School of MedicineDepartment of Systems Biology and Bioinformatics, University of RostockDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDepartment of Physiology and Biophysics, University of Colorado School of MedicineDepartment of Cardiac Surgery, Rostock University Medical CentreLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHDepartment of Biosciences, Università degli Studi di MilanoLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHThe Wellcome Trust Centre for Human GeneticsThe Wellcome Trust Centre for Human GeneticsThe Wellcome Trust Centre for Human GeneticsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordThe Wellcome Trust Centre for Human GeneticsDepartment of Medicine, BHF Laboratories, The Rayne Institute, University College LondonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordInstituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas GeraisCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College LondonCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College LondonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordNuffield Department of Clinical Laboratory Science, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordDepartment of Medicine, BHF Laboratories, The Rayne Institute, University College LondonDepartment of Systems Biology and Bioinformatics, University of RostockDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordThe Wellcome Trust Centre for Human GeneticsInstituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas GeraisBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of OxfordDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College LondonDepartment of Physiology and Biophysics, University of Colorado School of MedicineDepartment of Cardiac Surgery, Rostock University Medical CentreDepartment of Biosciences, Università degli Studi di MilanoDepartment of Biosciences, Università degli Studi di MilanoLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIHDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of OxfordExperimental Therapeutics, Radcliffe Department of Medicine, University of OxfordAMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.https://doi.org/10.1038/s41467-017-01342-5 |