FYN, SARS-CoV-2, and IFITM3 in the neurobiology of Alzheimer's disease
Introduction: (IFITM3) is an innate immune protein that has been identified as a novel γ-secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane, primes APP for amyloidogenic γs processing and mediates tau oligomerization. The purpose of this study is to explore the role of...
Main Authors: | George D. Vavougios, Marianthi Breza, Theodore Mavridis, Karen Angeliki Krogfelt |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-09-01
|
Series: | Brain Disorders |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459321000214 |
Similar Items
-
Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s disease
by: George D. Vavougios, et al.
Published: (2021-07-01) -
The IFITMs Inhibit Zika Virus Replication
by: George Savidis, et al.
Published: (2016-06-01) -
Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
by: Carmela Matrone, et al.
Published: (2020-06-01) -
Membrane Interference Against HIV-1 by Intrinsic Antiviral Factors: The Case of IFITMs
by: Federico Marziali, et al.
Published: (2021-05-01) -
The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3
by: Theodore A. Gobillot, et al.
Published: (2020-05-01)