Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview
Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence...
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| Format: | Article |
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MDPI AG
2011-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/5/3933/ |
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doaj-93df453953c14933aac261b1b2604baf2020-11-25T00:28:32ZengMDPI AGMolecules1420-30492011-05-011653933396810.3390/molecules16053933Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An OverviewJosé KovenskyAnne WadouachiUronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence of the electron-withdrawing C-5 carboxylic group. Herein we present an overview of glucuronidation, mannuronidation and galacturonidation reactions, including syntheses of prodrugs, oligosaccharides and stereochemical aspects.http://www.mdpi.com/1420-3049/16/5/3933/glycosidationglucuronic acidgalacturonic acidmannuronic acidstereoselectivity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
José Kovensky Anne Wadouachi |
| spellingShingle |
José Kovensky Anne Wadouachi Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview Molecules glycosidation glucuronic acid galacturonic acid mannuronic acid stereoselectivity |
| author_facet |
José Kovensky Anne Wadouachi |
| author_sort |
José Kovensky |
| title |
Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview |
| title_short |
Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview |
| title_full |
Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview |
| title_fullStr |
Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview |
| title_full_unstemmed |
Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview |
| title_sort |
synthesis of glycosides of glucuronic, galacturonic and mannuronic acids: an overview |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2011-05-01 |
| description |
Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence of the electron-withdrawing C-5 carboxylic group. Herein we present an overview of glucuronidation, mannuronidation and galacturonidation reactions, including syntheses of prodrugs, oligosaccharides and stereochemical aspects. |
| topic |
glycosidation glucuronic acid galacturonic acid mannuronic acid stereoselectivity |
| url |
http://www.mdpi.com/1420-3049/16/5/3933/ |
| work_keys_str_mv |
AT josekovensky synthesisofglycosidesofglucuronicgalacturonicandmannuronicacidsanoverview AT annewadouachi synthesisofglycosidesofglucuronicgalacturonicandmannuronicacidsanoverview |
| _version_ |
1725335597788168192 |