Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders
Epstein-Barr virus (EBV) was discovered 50 years ago from an African Burkitt lymphoma cell line. EBV-associated lymphoproliferative disorders (LPDs) are life-threatening diseases, especially in children. In this article, we review EBV-associated LPDs, especially in the area of primary immunodeficie...
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Tehran University of Medical Sciences
2015-10-01
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doaj-93e0fe6d0cf04cc1a51d46503eb918f42020-11-25T04:11:56ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492015-10-01145557Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative DisordersXi Yang0Naonori Nishida1Xiaodong Zhao2Hirokazu Kanegane3Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan AND Division of Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.Division of Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan AND Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Epstein-Barr virus (EBV) was discovered 50 years ago from an African Burkitt lymphoma cell line. EBV-associated lymphoproliferative disorders (LPDs) are life-threatening diseases, especially in children. In this article, we review EBV-associated LPDs, especially in the area of primary immunodeficiency disease (PID). We searched PubMed for publications with key words including EBV infection, lymphoma, LPDs and PID, and selected the manuscripts written in English that we judged to be relevant to the topic of this review. On the basis of the data in the literature, we grouped the EBV-associated LPDs into four categories: nonmalignant disease, malignant disease, acquired immunodeficiency disease and PID. Each category has its own risk factor for LPD development. EBV-associated LPD is a complex disease, creating new challenges for diagnosis and treatment. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/595Epstein-Barr virusLymphoproliferative disorderPrimary immunodeficiency disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xi Yang Naonori Nishida Xiaodong Zhao Hirokazu Kanegane |
spellingShingle |
Xi Yang Naonori Nishida Xiaodong Zhao Hirokazu Kanegane Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders Iranian Journal of Allergy, Asthma and Immunology Epstein-Barr virus Lymphoproliferative disorder Primary immunodeficiency disease |
author_facet |
Xi Yang Naonori Nishida Xiaodong Zhao Hirokazu Kanegane |
author_sort |
Xi Yang |
title |
Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders |
title_short |
Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders |
title_full |
Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders |
title_fullStr |
Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders |
title_full_unstemmed |
Advances in Understanding the Pathogenesis of Epstein-Barr Virus-Associated Lymphoproliferative Disorders |
title_sort |
advances in understanding the pathogenesis of epstein-barr virus-associated lymphoproliferative disorders |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2015-10-01 |
description |
Epstein-Barr virus (EBV) was discovered 50 years ago from an African Burkitt lymphoma cell line. EBV-associated lymphoproliferative disorders (LPDs) are life-threatening diseases, especially in children. In this article, we review EBV-associated LPDs, especially in the area of primary immunodeficiency disease (PID). We searched PubMed for publications with key words including EBV infection, lymphoma, LPDs and PID, and selected the manuscripts written in English that we judged to be relevant to the topic of this review. On the basis of the data in the literature, we grouped the EBV-associated LPDs into four categories: nonmalignant disease, malignant disease, acquired immunodeficiency disease and PID. Each category has its own risk factor for LPD development. EBV-associated LPD is a complex disease, creating new challenges for diagnosis and treatment.
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topic |
Epstein-Barr virus Lymphoproliferative disorder Primary immunodeficiency disease |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/595 |
work_keys_str_mv |
AT xiyang advancesinunderstandingthepathogenesisofepsteinbarrvirusassociatedlymphoproliferativedisorders AT naonorinishida advancesinunderstandingthepathogenesisofepsteinbarrvirusassociatedlymphoproliferativedisorders AT xiaodongzhao advancesinunderstandingthepathogenesisofepsteinbarrvirusassociatedlymphoproliferativedisorders AT hirokazukanegane advancesinunderstandingthepathogenesisofepsteinbarrvirusassociatedlymphoproliferativedisorders |
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1724416383534497792 |