Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China
Abstract Background Studies related to the SARS-CoV-2 spikes in the past few months, while there are limited studies on the entire outbreak-suppressed cycle of COVID-19. We estimate the cause-specific excess mortality during the complete circle of COVID-19 outbreak in Guangzhou, China, stratified by...
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doaj-93e51f0cddd24f62bfb528288cb1d7d52021-05-09T11:04:05ZengBMCBMC Public Health1471-24582021-05-0121111010.1186/s12889-021-10771-3Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, ChinaLi Li0Dong Hang1Han Dong2Chen Yuan-Yuan3Liang Bo-Heng4Yan Ze-Lin5Yang Zhou6Ou Chun-Quan7Qin Peng-Zhe8State Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityGuangzhou Center for Disease Control and PreventionState Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionState Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityGuangzhou Center for Disease Control and PreventionAbstract Background Studies related to the SARS-CoV-2 spikes in the past few months, while there are limited studies on the entire outbreak-suppressed cycle of COVID-19. We estimate the cause-specific excess mortality during the complete circle of COVID-19 outbreak in Guangzhou, China, stratified by sociodemographic status. Methods Guangzhou Center for Disease Control Prevention provided the individual data of deaths in Guangzhou from 1 January 2018 through 30 June 2020. We applied Poisson regression models to daily cause-specific mortality between 1 January 2018 and 20 January 2020, accounting for effects of population size, calendar time, holiday, ambient temperature and PM2.5. Expected mortality was estimated for the period from 21 January through 30 June 2020 assuming that the effects of factors aforementioned remained the same as described in the models. Excess mortality was defined as the difference between the observed mortality and the expected mortality. Subgroup analyses were performed by place of death, age group, sex, marital status and occupation class. Results From 21 January (the date on which the first COVID-19 case occurred in Guangzhou) through 30 June 2020, there were three stages of COVID-19: first wave, second wave, and recovery stage, starting on 21 January, 11 March, and 17 May 2020, respectively. Mortality deficits were seen from late February through early April and in most of the time in the recovery stage. Excesses in hypertension deaths occurred immediately after the starting weeks of the two waves. Overall, we estimated a deficit of 1051 (95% eCI: 580, 1558) in all-cause deaths. Particularly, comparing with the expected mortality in the absence of COVID-19 outbreak, the observed deaths from pneumonia and influenza substantially decreased by 49.2%, while deaths due to hypertension and myocardial infarction increased by 14.5 and 8.6%, respectively. In-hospital all-cause deaths dropped by 10.2%. There were discrepancies by age, marital status and occupation class in the excess mortality during the COVID-19 outbreak. Conclusions The excess deaths during the COVID-19 outbreak varied by cause of death and changed temporally. Overall, there was a deficit in deaths during the study period. Our findings can inform preparedness measures in different stages of the outbreak.https://doi.org/10.1186/s12889-021-10771-3Coronavirus disease 2019Excess mortalityTemporal dynamicSociodemographic statusGuangzhouChina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Li Dong Hang Han Dong Chen Yuan-Yuan Liang Bo-Heng Yan Ze-Lin Yang Zhou Ou Chun-Quan Qin Peng-Zhe |
spellingShingle |
Li Li Dong Hang Han Dong Chen Yuan-Yuan Liang Bo-Heng Yan Ze-Lin Yang Zhou Ou Chun-Quan Qin Peng-Zhe Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China BMC Public Health Coronavirus disease 2019 Excess mortality Temporal dynamic Sociodemographic status Guangzhou China |
author_facet |
Li Li Dong Hang Han Dong Chen Yuan-Yuan Liang Bo-Heng Yan Ze-Lin Yang Zhou Ou Chun-Quan Qin Peng-Zhe |
author_sort |
Li Li |
title |
Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China |
title_short |
Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China |
title_full |
Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China |
title_fullStr |
Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China |
title_full_unstemmed |
Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China |
title_sort |
temporal dynamic in the impact of covid− 19 outbreak on cause-specific mortality in guangzhou, china |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2021-05-01 |
description |
Abstract Background Studies related to the SARS-CoV-2 spikes in the past few months, while there are limited studies on the entire outbreak-suppressed cycle of COVID-19. We estimate the cause-specific excess mortality during the complete circle of COVID-19 outbreak in Guangzhou, China, stratified by sociodemographic status. Methods Guangzhou Center for Disease Control Prevention provided the individual data of deaths in Guangzhou from 1 January 2018 through 30 June 2020. We applied Poisson regression models to daily cause-specific mortality between 1 January 2018 and 20 January 2020, accounting for effects of population size, calendar time, holiday, ambient temperature and PM2.5. Expected mortality was estimated for the period from 21 January through 30 June 2020 assuming that the effects of factors aforementioned remained the same as described in the models. Excess mortality was defined as the difference between the observed mortality and the expected mortality. Subgroup analyses were performed by place of death, age group, sex, marital status and occupation class. Results From 21 January (the date on which the first COVID-19 case occurred in Guangzhou) through 30 June 2020, there were three stages of COVID-19: first wave, second wave, and recovery stage, starting on 21 January, 11 March, and 17 May 2020, respectively. Mortality deficits were seen from late February through early April and in most of the time in the recovery stage. Excesses in hypertension deaths occurred immediately after the starting weeks of the two waves. Overall, we estimated a deficit of 1051 (95% eCI: 580, 1558) in all-cause deaths. Particularly, comparing with the expected mortality in the absence of COVID-19 outbreak, the observed deaths from pneumonia and influenza substantially decreased by 49.2%, while deaths due to hypertension and myocardial infarction increased by 14.5 and 8.6%, respectively. In-hospital all-cause deaths dropped by 10.2%. There were discrepancies by age, marital status and occupation class in the excess mortality during the COVID-19 outbreak. Conclusions The excess deaths during the COVID-19 outbreak varied by cause of death and changed temporally. Overall, there was a deficit in deaths during the study period. Our findings can inform preparedness measures in different stages of the outbreak. |
topic |
Coronavirus disease 2019 Excess mortality Temporal dynamic Sociodemographic status Guangzhou China |
url |
https://doi.org/10.1186/s12889-021-10771-3 |
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