SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression

SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression

Proper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key regulators by the anaphase-promoting complex (APC) and Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligase complexes. But precisely how APC and SCF activities are coordinated to regulate cell-cycle progression rema...

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Bibliographic Details
Main Authors: Hidefumi Fukushima, Kohei Ogura, Lixin Wan, Ying Lu, Victor Li, Daming Gao, Pengda Liu, Alan W. Lau, Tao Wu, Marc W. Kirschner, Hiroyuki Inuzuka, Wenyi Wei
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003938

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