Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes
The transcription factor p63 is a key regulator in epidermal keratinocyte proliferation and differentiation. However, the role of p63 in gene regulation during these processes is not well understood. To investigate this, we recently generated genome-wide profiles of gene expression, p63 binding site...
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2015-09-01
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doaj-93f46654cd4c48a193f3f3185f6c18d82020-11-25T02:12:31ZengElsevierGenomics Data2213-59602015-09-015C15916310.1016/j.gdata.2015.06.002Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytesMartin Oti0Evelyn N. Kouwenhoven1Huiqing Zhou2Radboud University, Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Nijmegen, The NetherlandsRadboud University, Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Nijmegen, The NetherlandsRadboud University, Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Nijmegen, The NetherlandsThe transcription factor p63 is a key regulator in epidermal keratinocyte proliferation and differentiation. However, the role of p63 in gene regulation during these processes is not well understood. To investigate this, we recently generated genome-wide profiles of gene expression, p63 binding sites and active regulatory regions with the H3K27ac histone mark (Kouwenhoven et al., 2015). We showed that only a subset of p63 binding sites are active in keratinocytes, and that differentiation-associated gene expression dynamics correlate with the activity of p63 binding sites rather than with their occurrence per se. Here we describe in detail the generation and processing of the ChIP-seq and RNA-seq datasets used in this study. These data sets are deposited in the Gene Expression Omnibus (GEO) repository under the accession number GSE59827.http://www.sciencedirect.com/science/article/pii/S2213596015001038 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martin Oti Evelyn N. Kouwenhoven Huiqing Zhou |
spellingShingle |
Martin Oti Evelyn N. Kouwenhoven Huiqing Zhou Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes Genomics Data |
author_facet |
Martin Oti Evelyn N. Kouwenhoven Huiqing Zhou |
author_sort |
Martin Oti |
title |
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
title_short |
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
title_full |
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
title_fullStr |
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
title_full_unstemmed |
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
title_sort |
genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes |
publisher |
Elsevier |
series |
Genomics Data |
issn |
2213-5960 |
publishDate |
2015-09-01 |
description |
The transcription factor p63 is a key regulator in epidermal keratinocyte proliferation and differentiation. However, the role of p63 in gene regulation during these processes is not well understood. To investigate this, we recently generated genome-wide profiles of gene expression, p63 binding sites and active regulatory regions with the H3K27ac histone mark (Kouwenhoven et al., 2015). We showed that only a subset of p63 binding sites are active in keratinocytes, and that differentiation-associated gene expression dynamics correlate with the activity of p63 binding sites rather than with their occurrence per se. Here we describe in detail the generation and processing of the ChIP-seq and RNA-seq datasets used in this study. These data sets are deposited in the Gene Expression Omnibus (GEO) repository under the accession number GSE59827. |
url |
http://www.sciencedirect.com/science/article/pii/S2213596015001038 |
work_keys_str_mv |
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