Role of Epigenetics in the Pathogenesis of Asthma
Asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. Asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsib...
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Tehran University of Medical Sciences
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doaj-93f67be5d5074bb3b8213634d75d38112020-11-25T04:08:44ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492017-05-01162975Role of Epigenetics in the Pathogenesis of AsthmaZahra Alizadeh0Esmaeil Mortaz1Ian. Adcock2Mostafa Moin3Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, UKImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. Asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsible for the development of asthma. Increasing rate of asthma incidence during past decades has implicated the role of epigenetics in development of asthma. Environmental factors perform as initiator signals through epigenetic mechanisms. Three epigenetic mechanisms have been identified, including DNA methylation, histone modifications, and small noncoding RNAs. These mechanisms regulate the immune responses and inflammatory genes expression in asthma and allergy. This review explains the role of epigenetic modifications in controlling Th2 response and IgE production in asthma and also briefly overviews the role of environmental factors such as pollutions, allergens, prenatal exposures and diet in developing asthma. Recognizing environmental risk factors and their effects on epigenetic mechanisms would be of great interest for prognostic and preventive aspect in treatment of asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/975AsthmaDNA methylationEpigeneticsHistone modificationmiRNAEnvironmental factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zahra Alizadeh Esmaeil Mortaz Ian. Adcock Mostafa Moin |
spellingShingle |
Zahra Alizadeh Esmaeil Mortaz Ian. Adcock Mostafa Moin Role of Epigenetics in the Pathogenesis of Asthma Iranian Journal of Allergy, Asthma and Immunology Asthma DNA methylation Epigenetics Histone modification miRNA Environmental factors |
author_facet |
Zahra Alizadeh Esmaeil Mortaz Ian. Adcock Mostafa Moin |
author_sort |
Zahra Alizadeh |
title |
Role of Epigenetics in the Pathogenesis of Asthma |
title_short |
Role of Epigenetics in the Pathogenesis of Asthma |
title_full |
Role of Epigenetics in the Pathogenesis of Asthma |
title_fullStr |
Role of Epigenetics in the Pathogenesis of Asthma |
title_full_unstemmed |
Role of Epigenetics in the Pathogenesis of Asthma |
title_sort |
role of epigenetics in the pathogenesis of asthma |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2017-05-01 |
description |
Asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. Asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsible for the development of asthma. Increasing rate of asthma incidence during past decades has implicated the role of epigenetics in development of asthma. Environmental factors perform as initiator signals through epigenetic mechanisms. Three epigenetic mechanisms have been identified, including DNA methylation, histone modifications, and small noncoding RNAs. These mechanisms regulate the immune responses and inflammatory genes expression in asthma and allergy. This review explains the role of epigenetic modifications in controlling Th2 response and IgE production in asthma and also briefly overviews the role of environmental factors such as pollutions, allergens, prenatal exposures and diet in developing asthma. Recognizing environmental risk factors and their effects on epigenetic mechanisms would be of great interest for prognostic and preventive aspect in treatment of asthma.
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topic |
Asthma DNA methylation Epigenetics Histone modification miRNA Environmental factors |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/975 |
work_keys_str_mv |
AT zahraalizadeh roleofepigeneticsinthepathogenesisofasthma AT esmaeilmortaz roleofepigeneticsinthepathogenesisofasthma AT ianadcock roleofepigeneticsinthepathogenesisofasthma AT mostafamoin roleofepigeneticsinthepathogenesisofasthma |
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1724424267109498880 |