Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation

Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation

Background and objectives: Hepatic steatosis and inflammation are key characteristics of non-alcoholic fatty liver disease (NAFLD). However, whether and how hepatic steatosis and liver inflammation are differentially regulated remains to be elucidated. Considering that disruption of 6-phosphofructo-...

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Bibliographic Details
Main Authors: Xin Guo, Bilian Zhu, Hang Xu, Honggui Li, Boxiong Jiang, Yina Wang, Benrong Zheng, Shannon Glaser, Gianfranco Alpini, Chaodong Wu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-09-01
Series:Liver Research
Subjects:
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3/iPfk2)
Hematopoietic cells
Hepatic steatosis
Inflammation
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568420300404

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