Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation
Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM refere...
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doaj-940322349047469dbb00a5940e3191fc2020-11-25T01:35:52ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/69474716947471Metabolic Response in Rats following Electroacupuncture or Moxibustion StimulationJingjing Xu0Xianwei Lin1Kian-Kai Cheng2Huan Zhong3Mi Liu4Guoshan Zhang5Guiping Shen6Jiyang Dong7Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, ChinaDepartment of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, ChinaInnovation Centre in Agritechnology, Universiti Teknologi Malaysia, 84600 Muar, Johor, MalaysiaCollege of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Changsha 410007, ChinaCollege of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Changsha 410007, ChinaCollege of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Changsha 410007, ChinaDepartment of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, ChinaDepartment of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, ChinaElectroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treatment groups, regardless of meridian and mode of treatment, showed perturbation in cortex metabolome and increased phenylalanine, tyrosine, and branched-chain amino acids in liver. In addition, electroacupuncture was found to increase ATP in cortex, creatine, and dimethylglycine in stomach and GABA in liver. On the other hand, moxibustion increased plasma enkephalin concentration, as well as betaine and fumarate concentrations in stomach. Furthermore, we had observed meridian-specific changes including increased N-acetyl-aspartate in liver and 3-hydroxybutyrate in stomach for gallbladder meridian stimulation and increased noradrenaline concentration in blood plasma following stimulation on stomach meridian. In summary, the current findings may provide insight into the metabolic basis of electroacupuncture and moxibustion, which may contribute towards new application of acupoint stimulation.http://dx.doi.org/10.1155/2019/6947471 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jingjing Xu Xianwei Lin Kian-Kai Cheng Huan Zhong Mi Liu Guoshan Zhang Guiping Shen Jiyang Dong |
spellingShingle |
Jingjing Xu Xianwei Lin Kian-Kai Cheng Huan Zhong Mi Liu Guoshan Zhang Guiping Shen Jiyang Dong Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation Evidence-Based Complementary and Alternative Medicine |
author_facet |
Jingjing Xu Xianwei Lin Kian-Kai Cheng Huan Zhong Mi Liu Guoshan Zhang Guiping Shen Jiyang Dong |
author_sort |
Jingjing Xu |
title |
Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation |
title_short |
Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation |
title_full |
Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation |
title_fullStr |
Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation |
title_full_unstemmed |
Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation |
title_sort |
metabolic response in rats following electroacupuncture or moxibustion stimulation |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2019-01-01 |
description |
Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treatment groups, regardless of meridian and mode of treatment, showed perturbation in cortex metabolome and increased phenylalanine, tyrosine, and branched-chain amino acids in liver. In addition, electroacupuncture was found to increase ATP in cortex, creatine, and dimethylglycine in stomach and GABA in liver. On the other hand, moxibustion increased plasma enkephalin concentration, as well as betaine and fumarate concentrations in stomach. Furthermore, we had observed meridian-specific changes including increased N-acetyl-aspartate in liver and 3-hydroxybutyrate in stomach for gallbladder meridian stimulation and increased noradrenaline concentration in blood plasma following stimulation on stomach meridian. In summary, the current findings may provide insight into the metabolic basis of electroacupuncture and moxibustion, which may contribute towards new application of acupoint stimulation. |
url |
http://dx.doi.org/10.1155/2019/6947471 |
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