NADPH Oxidase: A Potential Target for Treatment of Stroke
Stroke is the third leading cause of death in industrialized nations. Oxidative stress is involved in the pathogenesis of stroke, and excessive generation of reactive oxygen species (ROS) by mitochondria is thought to be the main cause of oxidative stress. NADPH oxidase (NOX) enzymes have recently b...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2016/5026984 |
id |
doaj-9408a8d4269a4d8ea715d634ff7e47b1 |
---|---|
record_format |
Article |
spelling |
doaj-9408a8d4269a4d8ea715d634ff7e47b12020-11-24T23:38:04ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/50269845026984NADPH Oxidase: A Potential Target for Treatment of StrokeLi Zhang0Jie Wu1Xiaochun Duan2Xiaodi Tian3Haitao Shen4Qing Sun5Gang Chen6Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, ChinaStroke is the third leading cause of death in industrialized nations. Oxidative stress is involved in the pathogenesis of stroke, and excessive generation of reactive oxygen species (ROS) by mitochondria is thought to be the main cause of oxidative stress. NADPH oxidase (NOX) enzymes have recently been identified and studied as important producers of ROS in brain tissues after stroke. Several reports have shown that knockout or deletion of NOX exerts a neuroprotective effect in three major experimental stroke models. Recent studies also confirmed that NOX inhibitors ameliorate brain injury and improve neurological outcome after stroke. However, the physiological and pathophysiological roles of NOX enzymes in the central nervous system (CNS) are not known well. In this review, we provide a comprehensive summary of our current understanding about expression and physiological function of NOX enzymes in the CNS and its pathophysiological roles in the three major types of stroke: ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage.http://dx.doi.org/10.1155/2016/5026984 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Zhang Jie Wu Xiaochun Duan Xiaodi Tian Haitao Shen Qing Sun Gang Chen |
spellingShingle |
Li Zhang Jie Wu Xiaochun Duan Xiaodi Tian Haitao Shen Qing Sun Gang Chen NADPH Oxidase: A Potential Target for Treatment of Stroke Oxidative Medicine and Cellular Longevity |
author_facet |
Li Zhang Jie Wu Xiaochun Duan Xiaodi Tian Haitao Shen Qing Sun Gang Chen |
author_sort |
Li Zhang |
title |
NADPH Oxidase: A Potential Target for Treatment of Stroke |
title_short |
NADPH Oxidase: A Potential Target for Treatment of Stroke |
title_full |
NADPH Oxidase: A Potential Target for Treatment of Stroke |
title_fullStr |
NADPH Oxidase: A Potential Target for Treatment of Stroke |
title_full_unstemmed |
NADPH Oxidase: A Potential Target for Treatment of Stroke |
title_sort |
nadph oxidase: a potential target for treatment of stroke |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2016-01-01 |
description |
Stroke is the third leading cause of death in industrialized nations. Oxidative stress is involved in the pathogenesis of stroke, and excessive generation of reactive oxygen species (ROS) by mitochondria is thought to be the main cause of oxidative stress. NADPH oxidase (NOX) enzymes have recently been identified and studied as important producers of ROS in brain tissues after stroke. Several reports have shown that knockout or deletion of NOX exerts a neuroprotective effect in three major experimental stroke models. Recent studies also confirmed that NOX inhibitors ameliorate brain injury and improve neurological outcome after stroke. However, the physiological and pathophysiological roles of NOX enzymes in the central nervous system (CNS) are not known well. In this review, we provide a comprehensive summary of our current understanding about expression and physiological function of NOX enzymes in the CNS and its pathophysiological roles in the three major types of stroke: ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. |
url |
http://dx.doi.org/10.1155/2016/5026984 |
work_keys_str_mv |
AT lizhang nadphoxidaseapotentialtargetfortreatmentofstroke AT jiewu nadphoxidaseapotentialtargetfortreatmentofstroke AT xiaochunduan nadphoxidaseapotentialtargetfortreatmentofstroke AT xiaoditian nadphoxidaseapotentialtargetfortreatmentofstroke AT haitaoshen nadphoxidaseapotentialtargetfortreatmentofstroke AT qingsun nadphoxidaseapotentialtargetfortreatmentofstroke AT gangchen nadphoxidaseapotentialtargetfortreatmentofstroke |
_version_ |
1725517867170922496 |