Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome
CREST syndrome represents a form of scleroderma where the progressive autoimmune reaction is mainly manifested by the main symptoms, which make this acronym: calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and teleangiectasia. Among the first affected organs is the skin f...
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doaj-940fb4f9d9944d5dad68e28119034d572021-09-05T14:01:55ZengSciendoSerbian Journal of Dermatology and Venereology1821-09022406-06312018-03-011013710.2478/sjdv-2018-0001sjdv-2018-0001Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma SyndromeKocić Hristina0Stamenković Bojana1Popović Danijela2Zlatanović Zorana3Marković Tomislav4Tiodorović Danica5Medical Faculty University of Maribor,Manibor, SloveniaInstitute for Prevention, Treatment and Rehabilitation Niška Banja, Faculty of Medicine, University of Niš,Niš, SerbiaClinic of Dermatology, Clinical Centrer Niš,Niš, SerbiaClinic of Dermatology, Clinical Centrer Niš,Niš, SerbiaInstitute for Prevention, Treatment and Rehabilitation Niška Banja, Faculty of Medicine, University of Niš,Niš, SerbiaClinic of Dermatology, Faculty of Medicine, University of Niš,Niš, SerbiaCREST syndrome represents a form of scleroderma where the progressive autoimmune reaction is mainly manifested by the main symptoms, which make this acronym: calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and teleangiectasia. Among the first affected organs is the skin followed by the excessive fibrosis manifested by the deposition of collagen in dermis. Reactive oxygen species (ROS) theory has been underlined as one of the main pathogenetic mechanisms and triggering factor in development of scleroderma. The present study was aimed at estimating the marker of lipid peroxidation products (MDA) in plasma of patients with CREST syndrome having manifested symptoms of both Raynaud syndrome and positive ANA antibodies. The lipid peroxidation (MDA) level was significantly higher in the patients who had CREST syndrome and Raynaud syndrome for less than 10 years compared to the patients suffering from Raynoud syndrome for more than 10 years (p<0.05). Both groups were found to have a significant MDA level increase (p<0.001) compared to the control healthy subjects. In conclusion, the relationship between lipid peroxidation (MDA level) and Raynaud syndrome appearance may emphasize the role of ROS produced by the ischemia-reperfusion injury as an early pathogenetic mechanism in CREST scleroderma syndrome.https://doi.org/10.2478/sjdv-2018-0001crest syndromesclerodermasystemicraynaud diseasereactive oxygen speciesoxidative stresslipid peroxidationmalondialdehyde |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kocić Hristina Stamenković Bojana Popović Danijela Zlatanović Zorana Marković Tomislav Tiodorović Danica |
spellingShingle |
Kocić Hristina Stamenković Bojana Popović Danijela Zlatanović Zorana Marković Tomislav Tiodorović Danica Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome Serbian Journal of Dermatology and Venereology crest syndrome scleroderma systemic raynaud disease reactive oxygen species oxidative stress lipid peroxidation malondialdehyde |
author_facet |
Kocić Hristina Stamenković Bojana Popović Danijela Zlatanović Zorana Marković Tomislav Tiodorović Danica |
author_sort |
Kocić Hristina |
title |
Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome |
title_short |
Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome |
title_full |
Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome |
title_fullStr |
Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome |
title_full_unstemmed |
Possible Influence of Oxidative Stress on Development of Raynaud Phenomenon in Patients With CREST Scleroderma Syndrome |
title_sort |
possible influence of oxidative stress on development of raynaud phenomenon in patients with crest scleroderma syndrome |
publisher |
Sciendo |
series |
Serbian Journal of Dermatology and Venereology |
issn |
1821-0902 2406-0631 |
publishDate |
2018-03-01 |
description |
CREST syndrome represents a form of scleroderma where the progressive autoimmune reaction is mainly manifested by the main symptoms, which make this acronym: calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and teleangiectasia. Among the first affected organs is the skin followed by the excessive fibrosis manifested by the deposition of collagen in dermis. Reactive oxygen species (ROS) theory has been underlined as one of the main pathogenetic mechanisms and triggering factor in development of scleroderma. The present study was aimed at estimating the marker of lipid peroxidation products (MDA) in plasma of patients with CREST syndrome having manifested symptoms of both Raynaud syndrome and positive ANA antibodies. The lipid peroxidation (MDA) level was significantly higher in the patients who had CREST syndrome and Raynaud syndrome for less than 10 years compared to the patients suffering from Raynoud syndrome for more than 10 years (p<0.05). Both groups were found to have a significant MDA level increase (p<0.001) compared to the control healthy subjects. In conclusion, the relationship between lipid peroxidation (MDA level) and Raynaud syndrome appearance may emphasize the role of ROS produced by the ischemia-reperfusion injury as an early pathogenetic mechanism in CREST scleroderma syndrome. |
topic |
crest syndrome scleroderma systemic raynaud disease reactive oxygen species oxidative stress lipid peroxidation malondialdehyde |
url |
https://doi.org/10.2478/sjdv-2018-0001 |
work_keys_str_mv |
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