Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061.
Black men who have sex with men (MSM) in the United States (US) are affected by HIV at disproportionate rates compared to MSM of other race/ethnicities. Current HIV incidence estimates in this group are needed to appropriately target prevention efforts.From July 2009 to October 2010, Black MSM repor...
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doaj-9419ddc84bff4788852c04222dece1452020-11-25T02:06:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e7041310.1371/journal.pone.0070413Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061.Beryl A KoblinKenneth H MayerSusan H EshlemanLei WangSharon MannheimerCarlos del RioSteven ShoptawManya MagnusSusan BuchbinderLeo WiltonTing-Yuan LiuVanessa CummingsEstelle Piwowar-ManningSheldon D FieldsSam GriffithVanessa ElharrarDarrell WheelerHPTN 061 Protocol TeamBlack men who have sex with men (MSM) in the United States (US) are affected by HIV at disproportionate rates compared to MSM of other race/ethnicities. Current HIV incidence estimates in this group are needed to appropriately target prevention efforts.From July 2009 to October 2010, Black MSM reporting unprotected anal intercourse with a man in the past six months were enrolled and followed for one year in six US cities for a feasibility study of a multi-component intervention to reduce HIV infection. HIV incidence based on HIV seroconversion was calculated as number of events/100 person-years. Multivariate proportional hazards modeling with time-dependent covariates was used to identify correlates of HIV acquisition.Of 1,553 Black MSM enrolled, 1,164 were HIV-uninfected at baseline and included in follow-up. Overall annual HIV incidence was 3.0% (95% confidence interval (CI): 2.0, 4.4%) and 5.9% among men ≤30 years old (95% CI: 3.6, 9.1%). Men ≤30 years old reported significantly higher levels of sexual risk and were more likely to have a sexually transmitted infection diagnosed during follow-up. Younger men also were more likely to not have a usual place for health care, not have visited a health care provider recently, and to have unmet health care needs. In multivariate analysis, age ≤30 years (hazard ratio (HR): 3.4; 95% CI: 1.4, 8.3) and unprotected receptive anal intercourse with HIV-positive or unknown status partners (HR: 4.1; 95% CI: 1.9, 9.1) were significantly associated with HIV acquisition.In the largest cohort of prospectively-followed Black MSM in the US, HIV incidence was high, particularly among young men. Targeted, tailored and culturally appropriate HIV prevention strategies incorporating behavioral, social and biomedical based interventions are urgently needed to lower these rates.http://europepmc.org/articles/PMC3724810?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beryl A Koblin Kenneth H Mayer Susan H Eshleman Lei Wang Sharon Mannheimer Carlos del Rio Steven Shoptaw Manya Magnus Susan Buchbinder Leo Wilton Ting-Yuan Liu Vanessa Cummings Estelle Piwowar-Manning Sheldon D Fields Sam Griffith Vanessa Elharrar Darrell Wheeler HPTN 061 Protocol Team |
spellingShingle |
Beryl A Koblin Kenneth H Mayer Susan H Eshleman Lei Wang Sharon Mannheimer Carlos del Rio Steven Shoptaw Manya Magnus Susan Buchbinder Leo Wilton Ting-Yuan Liu Vanessa Cummings Estelle Piwowar-Manning Sheldon D Fields Sam Griffith Vanessa Elharrar Darrell Wheeler HPTN 061 Protocol Team Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. PLoS ONE |
author_facet |
Beryl A Koblin Kenneth H Mayer Susan H Eshleman Lei Wang Sharon Mannheimer Carlos del Rio Steven Shoptaw Manya Magnus Susan Buchbinder Leo Wilton Ting-Yuan Liu Vanessa Cummings Estelle Piwowar-Manning Sheldon D Fields Sam Griffith Vanessa Elharrar Darrell Wheeler HPTN 061 Protocol Team |
author_sort |
Beryl A Koblin |
title |
Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. |
title_short |
Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. |
title_full |
Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. |
title_fullStr |
Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. |
title_full_unstemmed |
Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. |
title_sort |
correlates of hiv acquisition in a cohort of black men who have sex with men in the united states: hiv prevention trials network (hptn) 061. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Black men who have sex with men (MSM) in the United States (US) are affected by HIV at disproportionate rates compared to MSM of other race/ethnicities. Current HIV incidence estimates in this group are needed to appropriately target prevention efforts.From July 2009 to October 2010, Black MSM reporting unprotected anal intercourse with a man in the past six months were enrolled and followed for one year in six US cities for a feasibility study of a multi-component intervention to reduce HIV infection. HIV incidence based on HIV seroconversion was calculated as number of events/100 person-years. Multivariate proportional hazards modeling with time-dependent covariates was used to identify correlates of HIV acquisition.Of 1,553 Black MSM enrolled, 1,164 were HIV-uninfected at baseline and included in follow-up. Overall annual HIV incidence was 3.0% (95% confidence interval (CI): 2.0, 4.4%) and 5.9% among men ≤30 years old (95% CI: 3.6, 9.1%). Men ≤30 years old reported significantly higher levels of sexual risk and were more likely to have a sexually transmitted infection diagnosed during follow-up. Younger men also were more likely to not have a usual place for health care, not have visited a health care provider recently, and to have unmet health care needs. In multivariate analysis, age ≤30 years (hazard ratio (HR): 3.4; 95% CI: 1.4, 8.3) and unprotected receptive anal intercourse with HIV-positive or unknown status partners (HR: 4.1; 95% CI: 1.9, 9.1) were significantly associated with HIV acquisition.In the largest cohort of prospectively-followed Black MSM in the US, HIV incidence was high, particularly among young men. Targeted, tailored and culturally appropriate HIV prevention strategies incorporating behavioral, social and biomedical based interventions are urgently needed to lower these rates. |
url |
http://europepmc.org/articles/PMC3724810?pdf=render |
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