Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
Purpose: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. Observations: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve...
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2020-12-01
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doaj-942bd55bb76e4d948ed7b8f1db7de9002020-12-21T04:46:50ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-12-0120100854Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatmentSarah M. Kamal0Kellen Riccobono1Alan Kwok2Jane C. Edmond3Stephen C. Pflugfelder4Department of Ophthalmology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA; Corresponding author.Boston Sight, 464 Hillside Ave, Needham, MA, 02494, USABoston Sight, 464 Hillside Ave, Needham, MA, 02494, USADepartment of Ophthalmology, Dell Medical School, University of Texas at Austin, 1701 Trinity St, Z1200, Austin, TX, 78712, USADepartment of Ophthalmology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USAPurpose: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. Observations: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve growth factor. Subsequent evaluation and fitting of a PROSE (prosthetic replacement of the ocular surface ecosystem) lens led to healing of the corneal epithelium and visual acuity improvement from 20/300 to 20/70. Conclusions and Importance: A scleral lens may be a possible treatment for those with neurotrophic keratitis in which a trial of topical lubrication and human nerve growth factor has not been effective.http://www.sciencedirect.com/science/article/pii/S2451993620301699Pediatric neurotrophic keratitisPROSE lensCongenital trigeminal nerve aplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah M. Kamal Kellen Riccobono Alan Kwok Jane C. Edmond Stephen C. Pflugfelder |
spellingShingle |
Sarah M. Kamal Kellen Riccobono Alan Kwok Jane C. Edmond Stephen C. Pflugfelder Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment American Journal of Ophthalmology Case Reports Pediatric neurotrophic keratitis PROSE lens Congenital trigeminal nerve aplasia |
author_facet |
Sarah M. Kamal Kellen Riccobono Alan Kwok Jane C. Edmond Stephen C. Pflugfelder |
author_sort |
Sarah M. Kamal |
title |
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment |
title_short |
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment |
title_full |
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment |
title_fullStr |
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment |
title_full_unstemmed |
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment |
title_sort |
unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with prose (prosthetic replacement of the ocular surface ecosystem) treatment |
publisher |
Elsevier |
series |
American Journal of Ophthalmology Case Reports |
issn |
2451-9936 |
publishDate |
2020-12-01 |
description |
Purpose: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. Observations: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve growth factor. Subsequent evaluation and fitting of a PROSE (prosthetic replacement of the ocular surface ecosystem) lens led to healing of the corneal epithelium and visual acuity improvement from 20/300 to 20/70. Conclusions and Importance: A scleral lens may be a possible treatment for those with neurotrophic keratitis in which a trial of topical lubrication and human nerve growth factor has not been effective. |
topic |
Pediatric neurotrophic keratitis PROSE lens Congenital trigeminal nerve aplasia |
url |
http://www.sciencedirect.com/science/article/pii/S2451993620301699 |
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