Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.

Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.

Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure. Rat cortical neuron preparations treated in medium alr...

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Bibliographic Details
Main Authors: Pascaline Clerc, Christina A Young, Evan A Bordt, Alina M Grigore, Gary Fiskum, Brian M Polster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827425?pdf=render

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