Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
Abstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients fr...
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doaj-943b02649c12449b9e08e9f55bde3b992021-04-11T11:29:07ZengNature Publishing GroupScientific Reports2045-23222021-04-011111910.1038/s41598-021-86711-3Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivoChenchen Ren0Xianxu Zeng1Zhongna Shi2Chunyan Wang3Huifen Wang4Xiuqin Wang5Baoping Zhang6Zhaoning Jiang7Huan Ma8Hao Hu9Haozhe Piao10Xiaoan Zhang11Baojin Wang12Department of Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Pathology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Gynecology, Liaoning Cancer Hospital and InstituteDepartment of Gynecology, Luohe Central HospitalDepartment of Gynecology, Puyang Oilfield General HospitalDepartment of Gynecology, Zhengzhou Jinshui District General HospitalZhengzhou Ultralucia Medical Technology Ltd.Zhengzhou Ultralucia Medical Technology Ltd.Zhengzhou Ultralucia Medical Technology Ltd.Department of Gynecology, Liaoning Cancer Hospital and InstituteDepartment of Imaging, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityAbstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.https://doi.org/10.1038/s41598-021-86711-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang |
spellingShingle |
Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo Scientific Reports |
author_facet |
Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang |
author_sort |
Chenchen Ren |
title |
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
title_short |
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
title_full |
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
title_fullStr |
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
title_full_unstemmed |
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
title_sort |
multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods. |
url |
https://doi.org/10.1038/s41598-021-86711-3 |
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