Complete response of penile mycosis fungoides with systemic brentuximab therapy
Mycosis fungoides with penile involvement is extremely rare. Previous reports have shown successful treatment with imiquimod or a combination of beam radiation and chemotherapy. We present a patient with mycosis fungoides and penile involvement. The penile lesions were initially treated with topical...
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doaj-943ca4775e9243edb32aa8f05972eb5c2020-12-15T04:09:37ZengElsevierUrology Case Reports2214-44202021-01-0134101460Complete response of penile mycosis fungoides with systemic brentuximab therapyChristian Schaufler0Katalin Ferenczi1Upendra Hegde2Benjamin T. Ristau3University of Connecticut Health Center, Division of Urology, 263 Farmington Avenue, Farmington, CT, 06030, United StatesUniversity of Connecticut Health Center, Division of Dermatology, 263 Farmington Avenue, Farmington, CT, 06030, United StatesUniversity of Connecticut Health Center, Division of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, United StatesUniversity of Connecticut Health Center, Division of Urology, 263 Farmington Avenue, Farmington, CT, 06030, United States; Corresponding author. UConn Health – Urology Outpatient Pavilion, 7th floor 263 Farmington Avenue Farmington, CT, 06030, United States.Mycosis fungoides with penile involvement is extremely rare. Previous reports have shown successful treatment with imiquimod or a combination of beam radiation and chemotherapy. We present a patient with mycosis fungoides and penile involvement. The penile lesions were initially treated with topical imiquimod; however, he developed worsening glandular lesions and discharge. Therefore the treatment was discontinued. Subsequent treatment with brentuximab (anti-CD30) targeted therapy resulted in complete resolution of the penile lesions. To our knowledge, this represents the first case of a complete penile mycosis fungoides response to brentuximab therapy. Brentuximab may be considered for refractory penile mycoses fungoides.http://www.sciencedirect.com/science/article/pii/S2214442020303491Mycosis fungoidesBrentuximabAnti-CD30ImiquimodRemission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christian Schaufler Katalin Ferenczi Upendra Hegde Benjamin T. Ristau |
spellingShingle |
Christian Schaufler Katalin Ferenczi Upendra Hegde Benjamin T. Ristau Complete response of penile mycosis fungoides with systemic brentuximab therapy Urology Case Reports Mycosis fungoides Brentuximab Anti-CD30 Imiquimod Remission |
author_facet |
Christian Schaufler Katalin Ferenczi Upendra Hegde Benjamin T. Ristau |
author_sort |
Christian Schaufler |
title |
Complete response of penile mycosis fungoides with systemic brentuximab therapy |
title_short |
Complete response of penile mycosis fungoides with systemic brentuximab therapy |
title_full |
Complete response of penile mycosis fungoides with systemic brentuximab therapy |
title_fullStr |
Complete response of penile mycosis fungoides with systemic brentuximab therapy |
title_full_unstemmed |
Complete response of penile mycosis fungoides with systemic brentuximab therapy |
title_sort |
complete response of penile mycosis fungoides with systemic brentuximab therapy |
publisher |
Elsevier |
series |
Urology Case Reports |
issn |
2214-4420 |
publishDate |
2021-01-01 |
description |
Mycosis fungoides with penile involvement is extremely rare. Previous reports have shown successful treatment with imiquimod or a combination of beam radiation and chemotherapy. We present a patient with mycosis fungoides and penile involvement. The penile lesions were initially treated with topical imiquimod; however, he developed worsening glandular lesions and discharge. Therefore the treatment was discontinued. Subsequent treatment with brentuximab (anti-CD30) targeted therapy resulted in complete resolution of the penile lesions. To our knowledge, this represents the first case of a complete penile mycosis fungoides response to brentuximab therapy. Brentuximab may be considered for refractory penile mycoses fungoides. |
topic |
Mycosis fungoides Brentuximab Anti-CD30 Imiquimod Remission |
url |
http://www.sciencedirect.com/science/article/pii/S2214442020303491 |
work_keys_str_mv |
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