Complete response of penile mycosis fungoides with systemic brentuximab therapy

• Main Authors: Christian Schaufler, Katalin Ferenczi, Upendra Hegde, Benjamin T. Ristau
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Urology Case Reports
• Subjects: Mycosis fungoides; Brentuximab; Anti-CD30; Imiquimod; Remission
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214442020303491

Mycosis fungoides with penile involvement is extremely rare. Previous reports have shown successful treatment with imiquimod or a combination of beam radiation and chemotherapy. We present a patient with mycosis fungoides and penile involvement. The penile lesions were initially treated with topical imiquimod; however, he developed worsening glandular lesions and discharge. Therefore the treatment was discontinued. Subsequent treatment with brentuximab (anti-CD30) targeted therapy resulted in complete resolution of the penile lesions. To our knowledge, this represents the first case of a complete penile mycosis fungoides response to brentuximab therapy. Brentuximab may be considered for refractory penile mycoses fungoides.