An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro.

An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro.

There is an urgent need for potent inhibitors of dengue virus (DENV) replication for the treatment and/or prophylaxis of infections with this virus. We here report on an aglycon analogue of the antibiotic teicoplanin (code name LCTA-949) that inhibits DENV-induced cytopathic effect (CPE) in a dose-d...

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Main Authors: Tine De Burghgraeve, Suzanne J F Kaptein, Nilda V Ayala-Nunez, Juan A Mondotte, Boris Pastorino, Svetlana S Printsevskaya, Xavier de Lamballerie, Michael Jacobs, Maria Preobrazhenskaya, Andrea V Gamarnik, Jolanda M Smit, Johan Neyts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3356272?pdf=render

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