Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterizati...
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doaj-9442c9af474a45a49449482fd3b593ce2020-11-25T02:29:39ZengMDPI AGAntibiotics2079-63822019-03-01812810.3390/antibiotics8010028antibiotics8010028Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other BacteriaJean Ferreira Machado0Maria do Socorro Costa1Saulo Relison Tintino2Fábio Fernandes Galvão Rodrigues3Camila Bezerra Nobre4Henrique Douglas Melo Coutinho5José Galberto Martins da Costa6Irwin Rose Alencar de Menezes7Erlânio Oliveira de Sousa8Technology Center, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilFaculty of Medicine of Juazeiro do Norte, Juazeiro do Norte 63041-190, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, BrazilTechnology Center, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, BrazilOrbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterization and its antibacterial activity in isolation and in association with aminoglycosides against standard and multidrug-resistant bacteria. Analyses such as water content, pH, acidity, peroxide index, relative density, and refractive index indicate the stability and chemical quality of the oil. In the oil’s GC/MS chemical composition analysis, a high saturated fatty acid (76.90%) content was observed. Lauric acid (56.28%) and oleic acid (23.10%) were the major oil components. In the antibacterial test, a more significant oil activity was observed against K. pneumoniae KP-ATCC 10031 (minimal inhibitory concentration (MIC) = 406.37 μg/mL) and Staphylococcus aureus ATCC 6538 (MIC = 812.75 μg/mL), but for the other strains—including standard and multi-resistant strains—the oil presented an MIC ≥ 1024 μg/mL. Furthermore, a synergistic effect was observed when the oil was associated with amikacin and gentamicin against S. aureus (SA-10) and an antagonistic effect was observed with amikacin against Escherichia coli. Data indicate the O. speciosa oil as a valuable nutritional source of lauric, oleic, and myristic fatty acids with an ability to modulate aminoglycoside activity.http://www.mdpi.com/2079-6382/8/1/28Orbignya speciosababassufatty acidanti-bacterialaminoglycosides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean Ferreira Machado Maria do Socorro Costa Saulo Relison Tintino Fábio Fernandes Galvão Rodrigues Camila Bezerra Nobre Henrique Douglas Melo Coutinho José Galberto Martins da Costa Irwin Rose Alencar de Menezes Erlânio Oliveira de Sousa |
spellingShingle |
Jean Ferreira Machado Maria do Socorro Costa Saulo Relison Tintino Fábio Fernandes Galvão Rodrigues Camila Bezerra Nobre Henrique Douglas Melo Coutinho José Galberto Martins da Costa Irwin Rose Alencar de Menezes Erlânio Oliveira de Sousa Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria Antibiotics Orbignya speciosa babassu fatty acid anti-bacterial aminoglycosides |
author_facet |
Jean Ferreira Machado Maria do Socorro Costa Saulo Relison Tintino Fábio Fernandes Galvão Rodrigues Camila Bezerra Nobre Henrique Douglas Melo Coutinho José Galberto Martins da Costa Irwin Rose Alencar de Menezes Erlânio Oliveira de Sousa |
author_sort |
Jean Ferreira Machado |
title |
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria |
title_short |
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria |
title_full |
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria |
title_fullStr |
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria |
title_full_unstemmed |
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria |
title_sort |
antibiotic activity potentiation and physicochemical characterization of the fixed orbignya speciosa almond oil against mdr staphylococcus aureus and other bacteria |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2019-03-01 |
description |
Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterization and its antibacterial activity in isolation and in association with aminoglycosides against standard and multidrug-resistant bacteria. Analyses such as water content, pH, acidity, peroxide index, relative density, and refractive index indicate the stability and chemical quality of the oil. In the oil’s GC/MS chemical composition analysis, a high saturated fatty acid (76.90%) content was observed. Lauric acid (56.28%) and oleic acid (23.10%) were the major oil components. In the antibacterial test, a more significant oil activity was observed against K. pneumoniae KP-ATCC 10031 (minimal inhibitory concentration (MIC) = 406.37 μg/mL) and Staphylococcus aureus ATCC 6538 (MIC = 812.75 μg/mL), but for the other strains—including standard and multi-resistant strains—the oil presented an MIC ≥ 1024 μg/mL. Furthermore, a synergistic effect was observed when the oil was associated with amikacin and gentamicin against S. aureus (SA-10) and an antagonistic effect was observed with amikacin against Escherichia coli. Data indicate the O. speciosa oil as a valuable nutritional source of lauric, oleic, and myristic fatty acids with an ability to modulate aminoglycoside activity. |
topic |
Orbignya speciosa babassu fatty acid anti-bacterial aminoglycosides |
url |
http://www.mdpi.com/2079-6382/8/1/28 |
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