Efficacy of Tumor-Targeting <i>Salmonella typhimurium</i> A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models

Efficacy of Tumor-Targeting <i>Salmonella typhimurium</i> A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models

We developed tumor-targeting <i>Salmonella typhimurium</i> (<i>S. typhimurium</i>) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of <i>S. typhimurium</i> A1-R was demonstrated in vivo and vitro using severa...

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Bibliographic Details
Main Authors: Takashi Murakami, Yukihiko Hiroshima, Kentaro Miyake, Tasuku Kiyuna, Itaru Endo, Ming Zhao, Robert M. Hoffman
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
<i>Salmonella typhimurium</i> A1-R
tumor-targeting
patient-derived orthotopic xenograft
malignancy
bacterial therapy
Online Access:https://www.mdpi.com/2073-4409/8/6/599

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