Prognostic value of microvessel density in cervical cancer
Abstract Background Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between mi...
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doaj-944903dbe7d04751b23eb5ae7d9cc71c2020-11-25T01:24:21ZengBMCCancer Cell International1475-28672018-10-0118111210.1186/s12935-018-0647-3Prognostic value of microvessel density in cervical cancerXiaoli Hu0Hailing Liu1Miaomiao Ye2Xueqiong Zhu3Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityAbstract Background Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer. Method There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017. Based on a fixed-effects or random-effects model, the hazard ratio (HR) and 95% confidence intervals (CIs) were calculated from researches on overall survival (OS) and disease-free survival (DFS). Result Totally, we included 13 observational researches, involving 1097 patients with cervical cancer. The results showed that high level of microvessel density was negatively correlated with OS (HR = 1.79, 95% CIs 1.31–2.44, I 2 = 60.7%, P = 0.003) and DFS (HR = 1.47, 95% CIs 1.13–1.80, I 2 = 0%, P = 0.423) of cervical cancer patients. In subgroup analysis, high counts of MVD were significantly associated with a poor survival (including OS and DFS) of the patients detected by anti-factor VIII antibodies or in European origin. Conclusion The present meta-analysis indicated that survival with high level of MVD was significant poorer than with low MVD in cervical cancer patient. Standardization of MVD assessment is needed.http://link.springer.com/article/10.1186/s12935-018-0647-3Microvessel densitySurvivalCervical neoplasiaMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoli Hu Hailing Liu Miaomiao Ye Xueqiong Zhu |
spellingShingle |
Xiaoli Hu Hailing Liu Miaomiao Ye Xueqiong Zhu Prognostic value of microvessel density in cervical cancer Cancer Cell International Microvessel density Survival Cervical neoplasia Meta-analysis |
author_facet |
Xiaoli Hu Hailing Liu Miaomiao Ye Xueqiong Zhu |
author_sort |
Xiaoli Hu |
title |
Prognostic value of microvessel density in cervical cancer |
title_short |
Prognostic value of microvessel density in cervical cancer |
title_full |
Prognostic value of microvessel density in cervical cancer |
title_fullStr |
Prognostic value of microvessel density in cervical cancer |
title_full_unstemmed |
Prognostic value of microvessel density in cervical cancer |
title_sort |
prognostic value of microvessel density in cervical cancer |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2018-10-01 |
description |
Abstract Background Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer. Method There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017. Based on a fixed-effects or random-effects model, the hazard ratio (HR) and 95% confidence intervals (CIs) were calculated from researches on overall survival (OS) and disease-free survival (DFS). Result Totally, we included 13 observational researches, involving 1097 patients with cervical cancer. The results showed that high level of microvessel density was negatively correlated with OS (HR = 1.79, 95% CIs 1.31–2.44, I 2 = 60.7%, P = 0.003) and DFS (HR = 1.47, 95% CIs 1.13–1.80, I 2 = 0%, P = 0.423) of cervical cancer patients. In subgroup analysis, high counts of MVD were significantly associated with a poor survival (including OS and DFS) of the patients detected by anti-factor VIII antibodies or in European origin. Conclusion The present meta-analysis indicated that survival with high level of MVD was significant poorer than with low MVD in cervical cancer patient. Standardization of MVD assessment is needed. |
topic |
Microvessel density Survival Cervical neoplasia Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12935-018-0647-3 |
work_keys_str_mv |
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