Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer

Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer

Background: Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies. Here we established prototype foamyviral vectors (FVV) that are derived from apathoge...

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Bibliographic Details
Main Authors: Nicole Armbruster, Jennifer Krieg, Manuel Weißenberger, Carsten Scheller, Andre F. Steinert
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
mesenchymal stem cell
chondrogenesis
pellet culture
foamy virus
virus vectors
IL1RA
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00255/full

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