Oral Food Challenge
Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic...
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doaj-946fe477f94946d7822755168e3a37aa2020-11-25T01:42:23ZengMDPI AGMedicina1010-660X2019-09-01551065110.3390/medicina55100651medicina55100651Oral Food ChallengeMauro Calvani0Annamaria Bianchi1Chiara Reginelli2Martina Peresso3Alessia Testa4Operative Unit of Paediatrics, S. Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152 Rome, ItalyOperative Unit of Paediatrics, S. Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152 Rome, ItalyDepartment of Paediatrics, Sapienza University of Rome, Viale Del Policlinico 155, 00161 Roma, ItalyDepartment of Paediatrics, Sapienza University of Rome, Viale Del Policlinico 155, 00161 Roma, ItalyDepartment of Paediatrics, Sapienza University of Rome, Viale Del Policlinico 155, 00161 Roma, ItalyOral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP).https://www.mdpi.com/1010-660X/55/10/651oral food challengefood allergyfood allergenssingle-blindplacebo-controlled oral food challengedouble-blindplacebo-controlled oral food challenge |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mauro Calvani Annamaria Bianchi Chiara Reginelli Martina Peresso Alessia Testa |
spellingShingle |
Mauro Calvani Annamaria Bianchi Chiara Reginelli Martina Peresso Alessia Testa Oral Food Challenge Medicina oral food challenge food allergy food allergens single-blind placebo-controlled oral food challenge double-blind placebo-controlled oral food challenge |
author_facet |
Mauro Calvani Annamaria Bianchi Chiara Reginelli Martina Peresso Alessia Testa |
author_sort |
Mauro Calvani |
title |
Oral Food Challenge |
title_short |
Oral Food Challenge |
title_full |
Oral Food Challenge |
title_fullStr |
Oral Food Challenge |
title_full_unstemmed |
Oral Food Challenge |
title_sort |
oral food challenge |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2019-09-01 |
description |
Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP). |
topic |
oral food challenge food allergy food allergens single-blind placebo-controlled oral food challenge double-blind placebo-controlled oral food challenge |
url |
https://www.mdpi.com/1010-660X/55/10/651 |
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