Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities
Multiple discoveries made since the identification of vesicular glutamate transporters (VGLUTs) two decades ago revealed that many neuronal populations in the brain use glutamate in addition to their “primary” neurotransmitter. Such a mode of cotransmission has been detected in dopamine (DA), acetyl...
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doaj-947157eddee7480f92303dbd15d599892020-11-24T21:45:00ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102018-12-011210.3389/fncir.2018.00113421761Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and CommonalitiesLouis-Eric Trudeau0Salah El Mestikawy1Salah El Mestikawy2CNS Research Group, Department of Pharmacology and Physiology, Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, CanadaDepartment of Psychiatry, Faculty of Medicine, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaSorbonne Universités, Université Pierre et Marie Curie UM 119—CNRS UMR 8246—INSERM U1130, Neurosciences Paris Seine—Institut de Biologie Paris Seine (NPS—IBPS), Paris, FranceMultiple discoveries made since the identification of vesicular glutamate transporters (VGLUTs) two decades ago revealed that many neuronal populations in the brain use glutamate in addition to their “primary” neurotransmitter. Such a mode of cotransmission has been detected in dopamine (DA), acetylcholine (ACh), serotonin (5-HT), norepinephrine (NE) and surprisingly even in GABA neurons. Interestingly, work performed by multiple groups during the past decade suggests that the use of glutamate as a cotransmitter takes different forms in these different populations of neurons. In the present review, we will provide an overview of glutamate cotransmission in these different classes of neurons, highlighting puzzling differences in: (1) the proportion of such neurons expressing a VGLUT in different brain regions and at different stages of development; (2) the sub-cellular localization of the VGLUT; (3) the localization of the VGLUT in relation to the neurons’ other vesicular transporter; and (4) the functional role of glutamate cotransmission.https://www.frontiersin.org/article/10.3389/fncir.2018.00113/fullcotransmissionglutamatevesicular transporterssynapseVGLUT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Louis-Eric Trudeau Salah El Mestikawy Salah El Mestikawy |
spellingShingle |
Louis-Eric Trudeau Salah El Mestikawy Salah El Mestikawy Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities Frontiers in Neural Circuits cotransmission glutamate vesicular transporters synapse VGLUT |
author_facet |
Louis-Eric Trudeau Salah El Mestikawy Salah El Mestikawy |
author_sort |
Louis-Eric Trudeau |
title |
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities |
title_short |
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities |
title_full |
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities |
title_fullStr |
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities |
title_full_unstemmed |
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities |
title_sort |
glutamate cotransmission in cholinergic, gabaergic and monoamine systems: contrasts and commonalities |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2018-12-01 |
description |
Multiple discoveries made since the identification of vesicular glutamate transporters (VGLUTs) two decades ago revealed that many neuronal populations in the brain use glutamate in addition to their “primary” neurotransmitter. Such a mode of cotransmission has been detected in dopamine (DA), acetylcholine (ACh), serotonin (5-HT), norepinephrine (NE) and surprisingly even in GABA neurons. Interestingly, work performed by multiple groups during the past decade suggests that the use of glutamate as a cotransmitter takes different forms in these different populations of neurons. In the present review, we will provide an overview of glutamate cotransmission in these different classes of neurons, highlighting puzzling differences in: (1) the proportion of such neurons expressing a VGLUT in different brain regions and at different stages of development; (2) the sub-cellular localization of the VGLUT; (3) the localization of the VGLUT in relation to the neurons’ other vesicular transporter; and (4) the functional role of glutamate cotransmission. |
topic |
cotransmission glutamate vesicular transporters synapse VGLUT |
url |
https://www.frontiersin.org/article/10.3389/fncir.2018.00113/full |
work_keys_str_mv |
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