Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line
A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP analysis confirmed a match to source T cells and also...
Main Authors: | Lucy Lin, Mavis R. Swerdel, Michael P. Lazaropoulos, Gary S. Hoffman, Alana J. Toro-Ramos, Jennifer Wright, Howard Lederman, Jianmin Chen, Jennifer C. Moore, Ronald P. Hart |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-12-01
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Series: | Stem Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213671115003070 |
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