The role of thiamine in neurodegenerative diseases
Vitamin B1 (thiamine) plays an important role in metabolism. It is indispensable for normal growth and development of the organism. Thiamine has a favourable impact on a number of systems, including the digestive, cardiovascular and nervous systems. It also stimulates the brain and improves the psyc...
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2015-09-01
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doaj-947bf6292e4d4e6a86aeb4ed9cf9fbd92020-11-25T02:51:25ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932015-09-01691096110610.5604/01.3001.0009.657901.3001.0009.6579The role of thiamine in neurodegenerative diseasesIrena Bubko0Beata M. Gruber1Elżbieta L. Anuszewska2Narodowy Instytut Leków, Zakład Biochemii i Biofarmaceutyków w WarszawieNarodowy Instytut Leków, Zakład Biochemii i Biofarmaceutyków w WarszawieAnuszewskaVitamin B1 (thiamine) plays an important role in metabolism. It is indispensable for normal growth and development of the organism. Thiamine has a favourable impact on a number of systems, including the digestive, cardiovascular and nervous systems. It also stimulates the brain and improves the psycho-emotional state. Hence it is often called the vitamin of “reassurance of the spirit”. Thiamine is a water-soluble vitamin. It can be present in the free form as thiamine or as its phosphate esters: mono-, di- or triphosphate. The main source of thiamine as an exogenous vitamin is certain foodstuffs, but trace amounts can be synthesised by microorganisms of the large intestine. The recommended daily intake of thiamine is about 2.0 mg. Since vitamin B1 has no ability to accumulate in the organism, manifestations of its deficiency begin to appear very quickly. The chronic state of thiamine deficiency, to a large extent, because of its function, contributes to the development of neurodegenerative diseases. It was proved that supporting vitamin B1 therapy not only constitutes neuroprotection but can also have a favourable impact on advanced neurodegenerative diseases. This article presents the current state of knowledge as regards the effects of thiamine exerted through this vitamin in a number of diseases such as Parkinson’s disease, Alzheimer’s disease, Wernicke’s encephalopathy or Wernicke-Korsakoff syndrome and Huntington’s disease. http://phmd.pl/gicid/01.3001.0009.6579tiaminadeficyt tiaminychoroby neurodegeneracyjneneuroprotekcjathiamineThiamine Deficiency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irena Bubko Beata M. Gruber Elżbieta L. Anuszewska |
spellingShingle |
Irena Bubko Beata M. Gruber Elżbieta L. Anuszewska The role of thiamine in neurodegenerative diseases Postępy Higieny i Medycyny Doświadczalnej tiamina deficyt tiaminy choroby neurodegeneracyjne neuroprotekcja thiamine Thiamine Deficiency |
author_facet |
Irena Bubko Beata M. Gruber Elżbieta L. Anuszewska |
author_sort |
Irena Bubko |
title |
The role of thiamine in neurodegenerative diseases |
title_short |
The role of thiamine in neurodegenerative diseases |
title_full |
The role of thiamine in neurodegenerative diseases |
title_fullStr |
The role of thiamine in neurodegenerative diseases |
title_full_unstemmed |
The role of thiamine in neurodegenerative diseases |
title_sort |
role of thiamine in neurodegenerative diseases |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2015-09-01 |
description |
Vitamin B1 (thiamine) plays an important role in metabolism. It is indispensable for normal growth and development of the organism. Thiamine has a favourable impact on a number of systems, including the digestive, cardiovascular and nervous systems. It also stimulates the brain and improves the psycho-emotional state. Hence it is often called the vitamin of “reassurance of the spirit”. Thiamine is a water-soluble vitamin. It can be present in the free form as thiamine or as its phosphate esters: mono-, di- or triphosphate. The main source of thiamine as an exogenous vitamin is certain foodstuffs, but trace amounts can be synthesised by microorganisms of the large intestine. The recommended daily intake of thiamine is about 2.0 mg. Since vitamin B1 has no ability to accumulate in the organism, manifestations of its deficiency begin to appear very quickly. The chronic state of thiamine deficiency, to a large extent, because of its function, contributes to the development of neurodegenerative diseases. It was proved that supporting vitamin B1 therapy not only constitutes neuroprotection but can also have a favourable impact on advanced neurodegenerative diseases. This article presents the current state of knowledge as regards the effects of thiamine exerted through this vitamin in a number of diseases such as Parkinson’s disease, Alzheimer’s disease, Wernicke’s encephalopathy or Wernicke-Korsakoff syndrome and Huntington’s disease.
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topic |
tiamina deficyt tiaminy choroby neurodegeneracyjne neuroprotekcja thiamine Thiamine Deficiency |
url |
http://phmd.pl/gicid/01.3001.0009.6579 |
work_keys_str_mv |
AT irenabubko theroleofthiamineinneurodegenerativediseases AT beatamgruber theroleofthiamineinneurodegenerativediseases AT elzbietalanuszewska theroleofthiamineinneurodegenerativediseases AT irenabubko roleofthiamineinneurodegenerativediseases AT beatamgruber roleofthiamineinneurodegenerativediseases AT elzbietalanuszewska roleofthiamineinneurodegenerativediseases |
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